Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents

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Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS...

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Autores principales: Burgueño, Adriana, Juárez, Yamila R., Genaro, Ana María, Tellechea, Mariana L.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2020
Materias:
ESTRES PRENATAL
SINDROME METABOLICO
HORMONAS
PRESION SANGUINEA
PESO AL NACER
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10053
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10053
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES PRENATAL
SINDROME METABOLICO
HORMONAS
PRESION SANGUINEA
PESO AL NACER
spellingShingle ESTRES PRENATAL
SINDROME METABOLICO
HORMONAS
PRESION SANGUINEA
PESO AL NACER
Burgueño, Adriana
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
topic_facet ESTRES PRENATAL
SINDROME METABOLICO
HORMONAS
PRESION SANGUINEA
PESO AL NACER
description Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations. Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE). Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP. Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.
format Artículo
author Burgueño, Adriana
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
author_facet Burgueño, Adriana
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
author_sort Burgueño, Adriana
title Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
title_short Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
title_full Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
title_fullStr Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
title_full_unstemmed Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
title_sort prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
publisher Elsevier
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10053
work_keys_str_mv AT burguenoadriana prenatalstressandlatermetabolicconsequencessystematicreviewandmetaanalysisinrodents
AT juarezyamilar prenatalstressandlatermetabolicconsequencessystematicreviewandmetaanalysisinrodents
AT genaroanamaria prenatalstressandlatermetabolicconsequencessystematicreviewandmetaanalysisinrodents
AT tellecheamarianal prenatalstressandlatermetabolicconsequencessystematicreviewandmetaanalysisinrodents
bdutipo_str Repositorios
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