Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch

Mostrar todas las versiones(2)

Abstract: Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting effects against an abnormal genetic background. Taurine is a ubiqui...

Descripción completa

Detalles Bibliográficos
Autores principales: Mensegue, Melisa F., Burgueño, Adriana Laura, Tellechea, Mariana L..
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2020
Materias:
OXIDO NITRICO
HIPERTENSION
TAURINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9976
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-9976
record_format dspace
spelling I33-R139-123456789-99762024-03-12T10:44:01Z Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch Mensegue, Melisa F. Burgueño, Adriana Laura Tellechea, Mariana L.. OXIDO NITRICO HIPERTENSION TAURINA Abstract: Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting effects against an abnormal genetic background. Taurine is a ubiquitous sulphur-containing amino acid present in foods such as seafood. The antihypertensive effects of taurine have been reported in experimental studies and in human hypertension. We aimed to investigate the effects of perinatal treatment with taurine in spontaneously hypertensive rats (SHR), a known model of genetic hypertension. Female SHR were administered with taurine (3 g/L) during gestation and lactation (SHR-TAU). Untreated SHR and Wistar-Kyoto rats (WKY) were used as controls. Long-lasting effects in offspring were investigated. Addition of taurine to the mother's drinking water reduced blood pressure in adult offspring. No differences were observed in cardiac hypertrophy. Findings on morphometric evaluations suggest that perinatal treatment with taurine would be partially effective in improving structural alterations of the aorta. Modifications in gene expression of Bcl-2 family members and upregulation of endothelial nitric oxide synthase in the aorta of 22-week-old male offspring were found. No differences were observed on relative telomere length in different cardiovascular tissues between SHR and SHR-TAU. Altogether results suggest that taurine programming, albeit sex specific, is associated with gene expression changes which ultimately may lead to improvement of aortic remodelling and enhanced endothelial function because of augmented nitric oxide (NO) production. 2020-05-13T21:50:37Z 2020-05-13T21:50:37Z 2020 Artículo Mensegue, M., Burgueño, A., Tellechea, L. Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch [en línea]. Clinical and Experimental Pharmacology and Physiology. 2020, 45(5). doi:10.1111/1440-1681.13260 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9976 0305-1870 (impreso) 1440-1681 (online) https://repositorio.uca.edu.ar/handle/123456789/9976 10.1111/1440-1681.13260 31958174 eng Acceso abierto. 12 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Clinical and Experimental Pharmacology and Physiology. 2020, 45(5)
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic OXIDO NITRICO
HIPERTENSION
TAURINA
spellingShingle OXIDO NITRICO
HIPERTENSION
TAURINA
Mensegue, Melisa F.
Burgueño, Adriana Laura
Tellechea, Mariana L..
Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
topic_facet OXIDO NITRICO
HIPERTENSION
TAURINA
description Abstract: Essential hypertension is considered to be a result of the interaction between genetic and environmental factors, including perinatal factors. Different advantageous perinatal factors proved to have beneficial long-lasting effects against an abnormal genetic background. Taurine is a ubiquitous sulphur-containing amino acid present in foods such as seafood. The antihypertensive effects of taurine have been reported in experimental studies and in human hypertension. We aimed to investigate the effects of perinatal treatment with taurine in spontaneously hypertensive rats (SHR), a known model of genetic hypertension. Female SHR were administered with taurine (3 g/L) during gestation and lactation (SHR-TAU). Untreated SHR and Wistar-Kyoto rats (WKY) were used as controls. Long-lasting effects in offspring were investigated. Addition of taurine to the mother's drinking water reduced blood pressure in adult offspring. No differences were observed in cardiac hypertrophy. Findings on morphometric evaluations suggest that perinatal treatment with taurine would be partially effective in improving structural alterations of the aorta. Modifications in gene expression of Bcl-2 family members and upregulation of endothelial nitric oxide synthase in the aorta of 22-week-old male offspring were found. No differences were observed on relative telomere length in different cardiovascular tissues between SHR and SHR-TAU. Altogether results suggest that taurine programming, albeit sex specific, is associated with gene expression changes which ultimately may lead to improvement of aortic remodelling and enhanced endothelial function because of augmented nitric oxide (NO) production.
format Artículo
author Mensegue, Melisa F.
Burgueño, Adriana Laura
Tellechea, Mariana L..
author_facet Mensegue, Melisa F.
Burgueño, Adriana Laura
Tellechea, Mariana L..
author_sort Mensegue, Melisa F.
title Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
title_short Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
title_full Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
title_fullStr Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
title_full_unstemmed Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
title_sort perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch
publisher Wiley
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9976
work_keys_str_mv AT menseguemelisaf perinataltaurineexertsahypotensiveeffectinmalespontaneouslyhypertensiveratsanddownregulatesendothelialoxidenitricsynthaseintheaorticarch
AT burguenoadrianalaura perinataltaurineexertsahypotensiveeffectinmalespontaneouslyhypertensiveratsanddownregulatesendothelialoxidenitricsynthaseintheaorticarch
AT tellecheamarianal perinataltaurineexertsahypotensiveeffectinmalespontaneouslyhypertensiveratsanddownregulatesendothelialoxidenitricsynthaseintheaorticarch
_version_ 1807949137737416704

Ejemplares similares