Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

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BACKGROUND: Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment...

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Autores principales: Burgueño, Adriana Laura, Juárez, Yamila R., Genaro, Ana María, Tellechea, Mariana L.
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
ESTRES PRENATAL
SINDROME METABOLICO
OBESIDAD
INDICE DE MASA CORPORAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9597
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-9597
record_format dspace
spelling I33-R139-123456789-95972024-03-12T10:42:43Z Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes Burgueño, Adriana Laura Juárez, Yamila R. Genaro, Ana María Tellechea, Mariana L. ESTRES PRENATAL SINDROME METABOLICO OBESIDAD INDICE DE MASA CORPORAL BACKGROUND: Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment that may impact the biology of the developing organism. The aim of this study was to quantitatively synthesize the available data on the effects of PS on offspring's obesity, estimated indirectly by body mass index (BMI) and body fat; blood pressure, plasma glucose and blood lipid concentrations (triglycerides and high-density lipoprotein cholesterol). METHODS: Literature searches for eligible studies on PubMed were conducted until October 8, 2018. Full text review yielded 24 publications for inclusion into the systematic review. Meta-analyses were performed for the outcomes BMI and body fat. 62 effect sizes from 19 studies together with relevant moderators were collected. Summary estimates were calculated by using random-effects model. RESULTS: The combined standardized mean difference (d) for the relation between BMI and PS indicated that despite significant heterogeneity, stress exposure of expectant mothers was associated with increased BMI of their offspring [d (95% CI) = 0.268 (0.191; 0.345)]. Both objective and subjective stress have been linked to increased overweight. Preliminary results of the relationship between PS and body fat suggested that the contribution of PS to body fat should be at least further considered [d (95% CI) = 0.167 (0.016; 0.317)]. Evidence from a limited number of published studies do not sustains an effect on blood pressure, glucose metabolism or circulating lipids, however these outcomes have only been scarcely investigated. CONCLUSIONS: A direct association between PS and BMI was found and further studies are needed to confirm the relationship between maternal stress during gestation and body fat. Overall, findings suggest that PS could contribute to alterations to the post-natal offspring phenotype. 2020-03-27T20:53:47Z 2020-03-27T20:53:47Z 2020 Artículo Burgueño, A. et al. Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes [en línea]. International Journal of Obesity. 2020, 44. doi:10.1038/s41366-019-0423-z Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9597 0307-0565 (impreso) 1476-5497 (online) https://repositorio.uca.edu.ar/handle/123456789/9597 10.1038/s41366-019-0423-z 31332277 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Nature International Journal of Obesity. 2020, 44
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES PRENATAL
SINDROME METABOLICO
OBESIDAD
INDICE DE MASA CORPORAL
spellingShingle ESTRES PRENATAL
SINDROME METABOLICO
OBESIDAD
INDICE DE MASA CORPORAL
Burgueño, Adriana Laura
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
topic_facet ESTRES PRENATAL
SINDROME METABOLICO
OBESIDAD
INDICE DE MASA CORPORAL
description BACKGROUND: Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment that may impact the biology of the developing organism. The aim of this study was to quantitatively synthesize the available data on the effects of PS on offspring's obesity, estimated indirectly by body mass index (BMI) and body fat; blood pressure, plasma glucose and blood lipid concentrations (triglycerides and high-density lipoprotein cholesterol). METHODS: Literature searches for eligible studies on PubMed were conducted until October 8, 2018. Full text review yielded 24 publications for inclusion into the systematic review. Meta-analyses were performed for the outcomes BMI and body fat. 62 effect sizes from 19 studies together with relevant moderators were collected. Summary estimates were calculated by using random-effects model. RESULTS: The combined standardized mean difference (d) for the relation between BMI and PS indicated that despite significant heterogeneity, stress exposure of expectant mothers was associated with increased BMI of their offspring [d (95% CI) = 0.268 (0.191; 0.345)]. Both objective and subjective stress have been linked to increased overweight. Preliminary results of the relationship between PS and body fat suggested that the contribution of PS to body fat should be at least further considered [d (95% CI) = 0.167 (0.016; 0.317)]. Evidence from a limited number of published studies do not sustains an effect on blood pressure, glucose metabolism or circulating lipids, however these outcomes have only been scarcely investigated. CONCLUSIONS: A direct association between PS and BMI was found and further studies are needed to confirm the relationship between maternal stress during gestation and body fat. Overall, findings suggest that PS could contribute to alterations to the post-natal offspring phenotype.
format Artículo
author Burgueño, Adriana Laura
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
author_facet Burgueño, Adriana Laura
Juárez, Yamila R.
Genaro, Ana María
Tellechea, Mariana L.
author_sort Burgueño, Adriana Laura
title Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
title_short Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
title_full Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
title_fullStr Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
title_full_unstemmed Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
title_sort systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes
publisher Springer Nature
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9597
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AT genaroanamaria systematicreviewandmetaanalysisontherelationshipbetweenprenatalstressandmetabolicsyndromeintermediatephenotypes
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