A visible-light-sensitive caged serotonin

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Abstract: Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We...

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Autores principales: Cabrera, Ricardo, Filevich, Oscar, Athilingam, Jegath, Bender, Kevin J., Poskanzer, Kira E., Etchenique, Roberto, García Acosta, Beatriz
Formato: Artículo
Lenguaje:Inglés
Publicado: American Chemical Society 2019
Materias:
NEUROFISIOLOGIA
SEROTONINA
FOTOQUIMICA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8670
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-8670
record_format dspace
spelling I33-R139-123456789-86702024-03-21T10:31:48Z A visible-light-sensitive caged serotonin Cabrera, Ricardo Filevich, Oscar Athilingam, Jegath Bender, Kevin J. Poskanzer, Kira E. Etchenique, Roberto García Acosta, Beatriz NEUROFISIOLOGIA SEROTONINA FOTOQUIMICA Abstract: Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. 2019-08-30T18:08:20Z 2019-08-30T18:08:20Z 2017 Artículo Cabrera R, Filevich O, García-Acosta B, et al. A Visible-Light-Sensitive Caged Serotonin. ACS Chemical Neuroscience 2017;8(5):1036-1042. doi:10.1021/acschemneuro.7b00083 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8670 1948-7193 (print) 1948-7193 (online) https://repositorio.uca.edu.ar/handle/123456789/8670 10.1021/acschemneuro.7b00083 28460173 eng Acceso Abierto. 12 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society ACS Chemical Neuroscience 2017;8(5):1036-1042
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic NEUROFISIOLOGIA
SEROTONINA
FOTOQUIMICA
spellingShingle NEUROFISIOLOGIA
SEROTONINA
FOTOQUIMICA
Cabrera, Ricardo
Filevich, Oscar
Athilingam, Jegath
Bender, Kevin J.
Poskanzer, Kira E.
Etchenique, Roberto
García Acosta, Beatriz
A visible-light-sensitive caged serotonin
topic_facet NEUROFISIOLOGIA
SEROTONINA
FOTOQUIMICA
description Abstract: Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons.
format Artículo
author Cabrera, Ricardo
Filevich, Oscar
Athilingam, Jegath
Bender, Kevin J.
Poskanzer, Kira E.
Etchenique, Roberto
García Acosta, Beatriz
author_facet Cabrera, Ricardo
Filevich, Oscar
Athilingam, Jegath
Bender, Kevin J.
Poskanzer, Kira E.
Etchenique, Roberto
García Acosta, Beatriz
author_sort Cabrera, Ricardo
title A visible-light-sensitive caged serotonin
title_short A visible-light-sensitive caged serotonin
title_full A visible-light-sensitive caged serotonin
title_fullStr A visible-light-sensitive caged serotonin
title_full_unstemmed A visible-light-sensitive caged serotonin
title_sort visible-light-sensitive caged serotonin
publisher American Chemical Society
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8670
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