Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model

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Abstract: Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to...

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Autores principales: Herrera, María Inés, Otero Losada, Matilde, Udovin, Lucas Daniel, Kusnier, Carlos Federico, Kölliker Frers, Rodolfo, Souza, Wanderley de, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: 2019
Materias:
ASFIXIA NEONATAL
SISTEMA NERVIOSO
TRASTORNOS DEL NEURODESARROLLO
PSICOPATOLOGIA
NEUROPSICOLOGIA
BEBES
PSICOLOGIA
SINAPTOPATIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/6205
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-6205
record_format dspace
spelling I33-R139-123456789-62052024-03-26T10:26:06Z Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model Herrera, María Inés Otero Losada, Matilde Udovin, Lucas Daniel Kusnier, Carlos Federico Kölliker Frers, Rodolfo Souza, Wanderley de Capani, Francisco ASFIXIA NEONATAL SISTEMA NERVIOSO TRASTORNOS DEL NEURODESARROLLO PSICOPATOLOGIA NEUROPSICOLOGIA BEBES PSICOLOGIA SINAPTOPATIA Abstract: Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with highmorbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunctionwith perinatal asphyxia on the basis of updated evidence froman experimental model 2019-06-12T01:38:48Z 2019-06-12T01:38:48Z 2017 Artículo Herrera, M.I., Otero Losada, M., Udoven, L.D., Kusnler, C., Kölliker Frers, R., Souza, W., Capani, F. (2017). Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model [en línea]. Neural plasticity. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/6205 https://repositorio.uca.edu.ar/handle/123456789/6205 eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Neural Plasticity, 2017
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ASFIXIA NEONATAL
SISTEMA NERVIOSO
TRASTORNOS DEL NEURODESARROLLO
PSICOPATOLOGIA
NEUROPSICOLOGIA
BEBES
PSICOLOGIA
SINAPTOPATIA
spellingShingle ASFIXIA NEONATAL
SISTEMA NERVIOSO
TRASTORNOS DEL NEURODESARROLLO
PSICOPATOLOGIA
NEUROPSICOLOGIA
BEBES
PSICOLOGIA
SINAPTOPATIA
Herrera, María Inés
Otero Losada, Matilde
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Kölliker Frers, Rodolfo
Souza, Wanderley de
Capani, Francisco
Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
topic_facet ASFIXIA NEONATAL
SISTEMA NERVIOSO
TRASTORNOS DEL NEURODESARROLLO
PSICOPATOLOGIA
NEUROPSICOLOGIA
BEBES
PSICOLOGIA
SINAPTOPATIA
description Abstract: Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with highmorbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunctionwith perinatal asphyxia on the basis of updated evidence froman experimental model
format Artículo
author Herrera, María Inés
Otero Losada, Matilde
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Kölliker Frers, Rodolfo
Souza, Wanderley de
Capani, Francisco
author_facet Herrera, María Inés
Otero Losada, Matilde
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Kölliker Frers, Rodolfo
Souza, Wanderley de
Capani, Francisco
author_sort Herrera, María Inés
title Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
title_short Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
title_full Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
title_fullStr Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
title_full_unstemmed Could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
title_sort could perinatal asphyxia induce a synaptopathy? : new highlights from an experimental model
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/6205
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