Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study

Multimorbidity (two or more comorbidities) is common in patients with heart failure. The reported prevalence of multimorbidity in patients with heart failure ranges between 43% and 98% and varies among geographical regions. Multimorbidity complicates guideline-directed pharmacological treatment and...

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Autores principales: Gerhardt, Teresa, Gerhardt, Louisa M. S., Ouwerkerk, Wouter, Roth, Gregory A., Dickstein, Kenneth, Collins, Sean P., Cleland, John G. F., Dahlstrom, Ulf, Tay, Wan Ting, Ertl, Georg, Hassanein, Mahmoud, Perrone, Sergio V., Ghadanfar, Mathieu, Schweizer, Anja, Obergfell, Achim, Filippatos, Gerasimos, Lam, Carolyn S. P., Tromp, Jasper, Angermann, Christiane E.
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier 2025
Materias:
INSUFICIENCIA CARDIACA
COMORBILIDAD
FARMACOLOGIA
DISTRIBUCION DEL INGRESO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/20459
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-20459
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spelling I33-R139-123456789-204592025-11-18T14:15:32Z Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study Gerhardt, Teresa Gerhardt, Louisa M. S. Ouwerkerk, Wouter Roth, Gregory A. Dickstein, Kenneth Collins, Sean P. Cleland, John G. F. Dahlstrom, Ulf Tay, Wan Ting Ertl, Georg Hassanein, Mahmoud Perrone, Sergio V. Ghadanfar, Mathieu Schweizer, Anja Obergfell, Achim Filippatos, Gerasimos Lam, Carolyn S. P. Tromp, Jasper Angermann, Christiane E. INSUFICIENCIA CARDIACA COMORBILIDAD FARMACOLOGIA DISTRIBUCION DEL INGRESO Multimorbidity (two or more comorbidities) is common in patients with heart failure. The reported prevalence of multimorbidity in patients with heart failure ranges between 43% and 98% and varies among geographical regions. Multimorbidity complicates guideline-directed pharmacological treatment and worsens prognosis. Additionally, comorbidities in heart failure are important drivers of poor health-related quality of life and hospitalisations. Previous reports on the effect of multimorbidity in heart failure included a limited number of countries, predominantly from western Europe, Asia, and North America or were based on populations participating in clinical trials, in which patients with comorbidities such as (severe) renal failure or cancer are commonly excluded. Patients with heart failure from lower-income regions report fewer comorbidities, but are at higher risk of mortality than patients from higher-income regions. This finding suggests regional differences in medical surveillance or the prognostic impact of multimorbidity. Contemporaneous representative data on multimorbidity from a global heart failure population, which are needed to quantify international differences, are scarce. Furthermore, the effect of multimorbidity on heart failure treatment and non-heart failure related therapies for comorbidities have not been systematically evaluated. Therefore, this analysis aimed to assess prevalence, prognostic effect, and implications for treatment of multimorbidity across world regions in the global prospective Registry to Assess Medical Practice and Longitudinal Observation for Treatment of Heart Failure (REPORT-HF) cohort study. 2025-09-08T19:38:15Z 2025-09-08T19:38:15Z 2023 Artículo https://repositorio.uca.edu.ar/handle/123456789/20459 10.1016/S2214-109X(23)00408-4 spa Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier The Lancet Global Health. 11, 2023.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
topic INSUFICIENCIA CARDIACA
COMORBILIDAD
FARMACOLOGIA
DISTRIBUCION DEL INGRESO
spellingShingle INSUFICIENCIA CARDIACA
COMORBILIDAD
FARMACOLOGIA
DISTRIBUCION DEL INGRESO
Gerhardt, Teresa
Gerhardt, Louisa M. S.
Ouwerkerk, Wouter
Roth, Gregory A.
Dickstein, Kenneth
Collins, Sean P.
Cleland, John G. F.
Dahlstrom, Ulf
Tay, Wan Ting
Ertl, Georg
Hassanein, Mahmoud
Perrone, Sergio V.
Ghadanfar, Mathieu
Schweizer, Anja
Obergfell, Achim
Filippatos, Gerasimos
Lam, Carolyn S. P.
Tromp, Jasper
Angermann, Christiane E.
Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
topic_facet INSUFICIENCIA CARDIACA
COMORBILIDAD
FARMACOLOGIA
DISTRIBUCION DEL INGRESO
description Multimorbidity (two or more comorbidities) is common in patients with heart failure. The reported prevalence of multimorbidity in patients with heart failure ranges between 43% and 98% and varies among geographical regions. Multimorbidity complicates guideline-directed pharmacological treatment and worsens prognosis. Additionally, comorbidities in heart failure are important drivers of poor health-related quality of life and hospitalisations. Previous reports on the effect of multimorbidity in heart failure included a limited number of countries, predominantly from western Europe, Asia, and North America or were based on populations participating in clinical trials, in which patients with comorbidities such as (severe) renal failure or cancer are commonly excluded. Patients with heart failure from lower-income regions report fewer comorbidities, but are at higher risk of mortality than patients from higher-income regions. This finding suggests regional differences in medical surveillance or the prognostic impact of multimorbidity. Contemporaneous representative data on multimorbidity from a global heart failure population, which are needed to quantify international differences, are scarce. Furthermore, the effect of multimorbidity on heart failure treatment and non-heart failure related therapies for comorbidities have not been systematically evaluated. Therefore, this analysis aimed to assess prevalence, prognostic effect, and implications for treatment of multimorbidity across world regions in the global prospective Registry to Assess Medical Practice and Longitudinal Observation for Treatment of Heart Failure (REPORT-HF) cohort study.
format Artículo
author Gerhardt, Teresa
Gerhardt, Louisa M. S.
Ouwerkerk, Wouter
Roth, Gregory A.
Dickstein, Kenneth
Collins, Sean P.
Cleland, John G. F.
Dahlstrom, Ulf
Tay, Wan Ting
Ertl, Georg
Hassanein, Mahmoud
Perrone, Sergio V.
Ghadanfar, Mathieu
Schweizer, Anja
Obergfell, Achim
Filippatos, Gerasimos
Lam, Carolyn S. P.
Tromp, Jasper
Angermann, Christiane E.
author_facet Gerhardt, Teresa
Gerhardt, Louisa M. S.
Ouwerkerk, Wouter
Roth, Gregory A.
Dickstein, Kenneth
Collins, Sean P.
Cleland, John G. F.
Dahlstrom, Ulf
Tay, Wan Ting
Ertl, Georg
Hassanein, Mahmoud
Perrone, Sergio V.
Ghadanfar, Mathieu
Schweizer, Anja
Obergfell, Achim
Filippatos, Gerasimos
Lam, Carolyn S. P.
Tromp, Jasper
Angermann, Christiane E.
author_sort Gerhardt, Teresa
title Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
title_short Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
title_full Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
title_fullStr Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
title_full_unstemmed Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
title_sort multimorbidity in patients with acute heart failure across world regions and country income levels (report-hf): a prospective, multicentre, global cohort study
publisher Elsevier
publishDate 2025
url https://repositorio.uca.edu.ar/handle/123456789/20459
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