Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review

Objective: To update evidence-based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of...

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Autores principales: de Bie, Rob M.A., Katzenschlager, Regina, Swinnen, Bart E.K.S., Peball, Marina, Lim, Shen-Yang, Mestre, Tiago A., Pérez Lloret, Santiago, Coelho, Miguel, Aquino, Camila, Tan, Ai Huey, Bruno, Veronica, Dijk, Joke M., Heim, Beatrice, Lin, Chin-Hsien, Azevedo Kauppila, Linda, Litvan, Irene, Spijker, René, Seppi, Klaus, Costa, João, Sampaio, Cristina, Fox, Susan H., Silverdale, Monty A.
Formato: Artículo
Lenguaje:Inglés
Publicado: International Parkinson and Movement Disorder Society 2025
Materias:
ENFERMEDAD DE PARKINSON
DISCAPACIDAD MOTORA
TRATAMIENTO FARMACOLOGICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/20085
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-20085
record_format dspace
spelling I33-R139-123456789-200852025-07-11T05:03:03Z Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review de Bie, Rob M.A. Katzenschlager, Regina Swinnen, Bart E.K.S. Peball, Marina Lim, Shen-Yang Mestre, Tiago A. Pérez Lloret, Santiago Coelho, Miguel Aquino, Camila Tan, Ai Huey Bruno, Veronica Dijk, Joke M. Heim, Beatrice Lin, Chin-Hsien Azevedo Kauppila, Linda Litvan, Irene Spijker, René Seppi, Klaus Costa, João Sampaio, Cristina Fox, Susan H. Silverdale, Monty A. ENFERMEDAD DE PARKINSON DISCAPACIDAD MOTORA TRATAMIENTO FARMACOLOGICO Objective: To update evidence-based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated. The current review uses a new methodology, including the Cochrane Risk of Bias tool and a modified version of GRADE (Grading of Recommendations, Assessment, Development, and Evaluations). Methods: On January 1, 2023, a literature search was conducted without date limit in the MEDLINE, Embase, and Cochrane databases using the following search terms: Parkinson disease, levodopa and, for the Embase database, randomized controlled trial (RCT). The inclusion criteria for studies were: patients with PD, on oral levodopa therapy, experiencing motor fluctuations, investigating an intervention that was (commercially) available in at least one country, study design RCT, and with a follow-up duration of at least 3 months. Results: A total of 102 studies were included. Levodopa extended release, pramipexole immediate release and extended release, ropinirole immediate release, rotigotine, opicapone, safinamide, and bilateral subthalamic nucleus deep brain stimulation (DBS) were assessed as efficacious, and continuous intestinal levodopa infusion, continuous subcutaneous levodopa, continuous subcutaneous apomorphine, ropinirole prolonged release, ropinirole patch, entacapone, rasagiline, istradefylline, amantadine extended release, zonisamide, bilateral globus pallidus DBS, and pallidotomy were assessed as likely efficacious for the treatment of motor fluctuations in people with PD who are already being treated with levodopa. Conclusions: There are several treatment options that can improve motor fluctuations in PD. These recommendations will assist physicians and patients in determining which intervention to use. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2025-07-10T18:58:40Z 2025-07-10T18:58:40Z 2025 Artículo 1531-8257 0885-3185 https://repositorio.uca.edu.ar/handle/123456789/20085 10.1002/mds.30162 eng Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf International Parkinson and Movement Disorder Society Movement Disorders. 40(5), 2025.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE PARKINSON
DISCAPACIDAD MOTORA
TRATAMIENTO FARMACOLOGICO
spellingShingle ENFERMEDAD DE PARKINSON
DISCAPACIDAD MOTORA
TRATAMIENTO FARMACOLOGICO
de Bie, Rob M.A.
Katzenschlager, Regina
Swinnen, Bart E.K.S.
Peball, Marina
Lim, Shen-Yang
Mestre, Tiago A.
Pérez Lloret, Santiago
Coelho, Miguel
Aquino, Camila
Tan, Ai Huey
Bruno, Veronica
Dijk, Joke M.
Heim, Beatrice
Lin, Chin-Hsien
Azevedo Kauppila, Linda
Litvan, Irene
Spijker, René
Seppi, Klaus
Costa, João
Sampaio, Cristina
Fox, Susan H.
Silverdale, Monty A.
Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
topic_facet ENFERMEDAD DE PARKINSON
DISCAPACIDAD MOTORA
TRATAMIENTO FARMACOLOGICO
description Objective: To update evidence-based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated. The current review uses a new methodology, including the Cochrane Risk of Bias tool and a modified version of GRADE (Grading of Recommendations, Assessment, Development, and Evaluations). Methods: On January 1, 2023, a literature search was conducted without date limit in the MEDLINE, Embase, and Cochrane databases using the following search terms: Parkinson disease, levodopa and, for the Embase database, randomized controlled trial (RCT). The inclusion criteria for studies were: patients with PD, on oral levodopa therapy, experiencing motor fluctuations, investigating an intervention that was (commercially) available in at least one country, study design RCT, and with a follow-up duration of at least 3 months. Results: A total of 102 studies were included. Levodopa extended release, pramipexole immediate release and extended release, ropinirole immediate release, rotigotine, opicapone, safinamide, and bilateral subthalamic nucleus deep brain stimulation (DBS) were assessed as efficacious, and continuous intestinal levodopa infusion, continuous subcutaneous levodopa, continuous subcutaneous apomorphine, ropinirole prolonged release, ropinirole patch, entacapone, rasagiline, istradefylline, amantadine extended release, zonisamide, bilateral globus pallidus DBS, and pallidotomy were assessed as likely efficacious for the treatment of motor fluctuations in people with PD who are already being treated with levodopa. Conclusions: There are several treatment options that can improve motor fluctuations in PD. These recommendations will assist physicians and patients in determining which intervention to use. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
format Artículo
author de Bie, Rob M.A.
Katzenschlager, Regina
Swinnen, Bart E.K.S.
Peball, Marina
Lim, Shen-Yang
Mestre, Tiago A.
Pérez Lloret, Santiago
Coelho, Miguel
Aquino, Camila
Tan, Ai Huey
Bruno, Veronica
Dijk, Joke M.
Heim, Beatrice
Lin, Chin-Hsien
Azevedo Kauppila, Linda
Litvan, Irene
Spijker, René
Seppi, Klaus
Costa, João
Sampaio, Cristina
Fox, Susan H.
Silverdale, Monty A.
author_facet de Bie, Rob M.A.
Katzenschlager, Regina
Swinnen, Bart E.K.S.
Peball, Marina
Lim, Shen-Yang
Mestre, Tiago A.
Pérez Lloret, Santiago
Coelho, Miguel
Aquino, Camila
Tan, Ai Huey
Bruno, Veronica
Dijk, Joke M.
Heim, Beatrice
Lin, Chin-Hsien
Azevedo Kauppila, Linda
Litvan, Irene
Spijker, René
Seppi, Klaus
Costa, João
Sampaio, Cristina
Fox, Susan H.
Silverdale, Monty A.
author_sort de Bie, Rob M.A.
title Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
title_short Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
title_full Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
title_fullStr Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
title_full_unstemmed Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review
title_sort update on treatments for parkinson's disease motor fluctuations – an international parkinson and movement disorder society evidence‐based medicine review
publisher International Parkinson and Movement Disorder Society
publishDate 2025
url https://repositorio.uca.edu.ar/handle/123456789/20085
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