Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study

Introduction: The aim of this study was to characterize infradian rhythms in heart rate and blood pressure, as well as investigate potential synchronization of these parameters among participants in the Mars500 study. This study involved a 520-day simulated mission to Mars, during which six crew mem...

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Autores principales: Vigo, Daniel Eduardo, Tuerlinckx, Francis, Scaramal, Mariano, Reimann Baptista, Rafael, Bersenev, Evgeny, Van den Bergh, Omer, Aubert, André E.
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier 2025
Materias:
RITMO CIRCADIANO
SISTEMA CARDIOVASCULAR
CONFINAMIENTO
ASTRONAUTAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/19982
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-19982
record_format dspace
spelling I33-R139-123456789-199822025-07-04T05:01:18Z Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study Vigo, Daniel Eduardo Tuerlinckx, Francis Scaramal, Mariano Reimann Baptista, Rafael Bersenev, Evgeny Van den Bergh, Omer Aubert, André E. RITMO CIRCADIANO SISTEMA CARDIOVASCULAR CONFINAMIENTO ASTRONAUTAS Introduction: The aim of this study was to characterize infradian rhythms in heart rate and blood pressure, as well as investigate potential synchronization of these parameters among participants in the Mars500 study. This study involved a 520-day simulated mission to Mars, during which six crew members were confined for the entire duration of the experiment. Methods: The study involved daily measurements of blood pressure and heart rate, taken in the morning and evening for each participant. Mean differences were analyzed using a mixed model design, considering journey stage and time of day as fixed factors, and participant as a random factor. The Lomb-Scargle periodogram was used to identify rhythmic patterns in the data. Significant rhythms were described by fitting a cosine curve using a cosinor model. The level of synchronization between participants’ measurements was assessed by analyzing signal pairs using the Hilbert transform. Phase differences were measured in one-month bins using the gamma parameter. Surrogate data was employed for comparison with the observed data. Gamma differences between bins were evaluated using a mixed model design. Results: All signals showed significant changes over time, and most participants exhibited at least one significant infradian rhythm in the analyzed variables. The primary peaks varied between participants and variables, ranging from 22 days to 520 days. Interestingly, there was a consistent period of 173 days observed in the evening heart rate across all participants. Regarding synchronization, the gamma values of evening heart rate differed from surrogate data in all stages, except during the middle part of the mission. Discussion: The primary finding of this study is the identification of significant infradian rhythms in cardiovascular variables, specifically in evening heart rate, with a shared and synchronized period of 173 days among participants. We propose that affective changes associated with different stages of the mission, along with the cohesive functioning of the crew as a unit, may contribute to these variations. 2025-07-03T13:35:25Z 2025-07-03T13:35:25Z 2025 Artículo 1879-2030 0094-5765 https://repositorio.uca.edu.ar/handle/123456789/19982 10.1016/j.actaastro.2025.01.060 spa Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Acta Astronautica. 2025, 229.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
topic RITMO CIRCADIANO
SISTEMA CARDIOVASCULAR
CONFINAMIENTO
ASTRONAUTAS
spellingShingle RITMO CIRCADIANO
SISTEMA CARDIOVASCULAR
CONFINAMIENTO
ASTRONAUTAS
Vigo, Daniel Eduardo
Tuerlinckx, Francis
Scaramal, Mariano
Reimann Baptista, Rafael
Bersenev, Evgeny
Van den Bergh, Omer
Aubert, André E.
Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
topic_facet RITMO CIRCADIANO
SISTEMA CARDIOVASCULAR
CONFINAMIENTO
ASTRONAUTAS
description Introduction: The aim of this study was to characterize infradian rhythms in heart rate and blood pressure, as well as investigate potential synchronization of these parameters among participants in the Mars500 study. This study involved a 520-day simulated mission to Mars, during which six crew members were confined for the entire duration of the experiment. Methods: The study involved daily measurements of blood pressure and heart rate, taken in the morning and evening for each participant. Mean differences were analyzed using a mixed model design, considering journey stage and time of day as fixed factors, and participant as a random factor. The Lomb-Scargle periodogram was used to identify rhythmic patterns in the data. Significant rhythms were described by fitting a cosine curve using a cosinor model. The level of synchronization between participants’ measurements was assessed by analyzing signal pairs using the Hilbert transform. Phase differences were measured in one-month bins using the gamma parameter. Surrogate data was employed for comparison with the observed data. Gamma differences between bins were evaluated using a mixed model design. Results: All signals showed significant changes over time, and most participants exhibited at least one significant infradian rhythm in the analyzed variables. The primary peaks varied between participants and variables, ranging from 22 days to 520 days. Interestingly, there was a consistent period of 173 days observed in the evening heart rate across all participants. Regarding synchronization, the gamma values of evening heart rate differed from surrogate data in all stages, except during the middle part of the mission. Discussion: The primary finding of this study is the identification of significant infradian rhythms in cardiovascular variables, specifically in evening heart rate, with a shared and synchronized period of 173 days among participants. We propose that affective changes associated with different stages of the mission, along with the cohesive functioning of the crew as a unit, may contribute to these variations.
format Artículo
author Vigo, Daniel Eduardo
Tuerlinckx, Francis
Scaramal, Mariano
Reimann Baptista, Rafael
Bersenev, Evgeny
Van den Bergh, Omer
Aubert, André E.
author_facet Vigo, Daniel Eduardo
Tuerlinckx, Francis
Scaramal, Mariano
Reimann Baptista, Rafael
Bersenev, Evgeny
Van den Bergh, Omer
Aubert, André E.
author_sort Vigo, Daniel Eduardo
title Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
title_short Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
title_full Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
title_fullStr Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
title_full_unstemmed Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars500 prolonged confinement study
title_sort infradian cardiovascular rhythms and between subject cardiovascular coupling in mars500 prolonged confinement study
publisher Elsevier
publishDate 2025
url https://repositorio.uca.edu.ar/handle/123456789/19982
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