Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research

Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon ca...

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Autores principales: Salgueiro, Maria Jimena, Portillo, Mariano, Tesán, Fiorella, Nicoud, Melisa, Medina, Vanina, Moretton, Marcela, Chiappetta, Diego, Zubillaga, Marcela
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2025
Materias:
MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/19910
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-19910
record_format dspace
spelling I33-R139-123456789-199102025-06-04T05:00:29Z Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research Salgueiro, Maria Jimena Portillo, Mariano Tesán, Fiorella Nicoud, Melisa Medina, Vanina Moretton, Marcela Chiappetta, Diego Zubillaga, Marcela MEDICINA ONCOLOGIA CANCER NANOTECNOLOGIA Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images. 2025-06-03T14:34:47Z 2025-06-03T14:34:47Z 2024 Artículo 2365-421X https://repositorio.uca.edu.ar/handle/123456789/19910 10.1186/s41181-024-00300-z eng Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer EJNMMI Radiopharmacy and Chemistry. 9, 2024.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
spellingShingle MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
Salgueiro, Maria Jimena
Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
topic_facet MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
description Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images.
format Artículo
author Salgueiro, Maria Jimena
Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
author_facet Salgueiro, Maria Jimena
Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
author_sort Salgueiro, Maria Jimena
title Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_short Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_full Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_fullStr Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_full_unstemmed Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_sort design and development of nanoprobes radiolabelled with 99mtc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
publisher Springer
publishDate 2025
url https://repositorio.uca.edu.ar/handle/123456789/19910
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