Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina

Background: Although there is evidence that sitting time (ST) and insufficient physical activity (PA) are associated with premature mortality, the burden of cardiovascular disease (CVD) and all-cause mortality (ACM) attributable to the combined effects of ST and PA in counterfactual scenarios is lim...

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Autor principal: García-Witulski, Christian
Formato: Artículo
Lenguaje:Inglés
Publicado: Oxford Academic 2025
Materias:
MORTALIDAD
ENFERMEDADES CARDIOVASCULARES
SEDENTARISMO
ACTIVIDAD FISICA
EXPECTATIVA DE VIDA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/19906
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Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-19906
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spelling I33-R139-123456789-199062025-06-03T05:16:05Z Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina García-Witulski, Christian MORTALIDAD ENFERMEDADES CARDIOVASCULARES SEDENTARISMO ACTIVIDAD FISICA EXPECTATIVA DE VIDA Background: Although there is evidence that sitting time (ST) and insufficient physical activity (PA) are associated with premature mortality, the burden of cardiovascular disease (CVD) and all-cause mortality (ACM) attributable to the combined effects of ST and PA in counterfactual scenarios is limited. Methods: Potential impact fractions (PIFs) were used to calculate premature deaths (PDs) and disability-adjusted life years (DALYs). Cause-eliminated life tables were utilized to estimate health-adjusted life expectancy (HALE) gains. Monte Carlo simulations were performed for uncertainty analysis. Results: The theoretical minimum risk exposure level (ST < 4 ⁠, PA > 65 ⁠) could prevent 16.7% of CVD deaths and 12.3% of all-cause deaths annually. This would save 669 to 2,630 DALYs per 100,000 and increase healthy life years by 0.57 to 2.94. Increasing PA to > 65 while maintaining ST could yield gains in HALE from 0.49 (CVD) to 2.60 (ACM) years. Reducing ST to < 4 while keeping PA constant could lead to gains in HALE from 0.07 (CVD) to 0.34 (ACM) years. A 50% reduction in suboptimal ST (≥ 4⁠) doubled HALE gains, ranging from 0.11 to 0.63 years. Conclusions: Public health decision-makers should prioritize vulnerable populations, including older adults and individuals with inadequate PA levels. 2025-06-02T18:40:13Z 2025-06-02T18:40:13Z 2024 Artículo 1741-3850 1741-3842 https://repositorio.uca.edu.ar/handle/123456789/19906 10.1093/pubmed/fdae291 eng Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Oxford Academic Journal of Public Health. 47(1), 2024.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MORTALIDAD
ENFERMEDADES CARDIOVASCULARES
SEDENTARISMO
ACTIVIDAD FISICA
EXPECTATIVA DE VIDA
spellingShingle MORTALIDAD
ENFERMEDADES CARDIOVASCULARES
SEDENTARISMO
ACTIVIDAD FISICA
EXPECTATIVA DE VIDA
García-Witulski, Christian
Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
topic_facet MORTALIDAD
ENFERMEDADES CARDIOVASCULARES
SEDENTARISMO
ACTIVIDAD FISICA
EXPECTATIVA DE VIDA
description Background: Although there is evidence that sitting time (ST) and insufficient physical activity (PA) are associated with premature mortality, the burden of cardiovascular disease (CVD) and all-cause mortality (ACM) attributable to the combined effects of ST and PA in counterfactual scenarios is limited. Methods: Potential impact fractions (PIFs) were used to calculate premature deaths (PDs) and disability-adjusted life years (DALYs). Cause-eliminated life tables were utilized to estimate health-adjusted life expectancy (HALE) gains. Monte Carlo simulations were performed for uncertainty analysis. Results: The theoretical minimum risk exposure level (ST < 4 ⁠, PA > 65 ⁠) could prevent 16.7% of CVD deaths and 12.3% of all-cause deaths annually. This would save 669 to 2,630 DALYs per 100,000 and increase healthy life years by 0.57 to 2.94. Increasing PA to > 65 while maintaining ST could yield gains in HALE from 0.49 (CVD) to 2.60 (ACM) years. Reducing ST to < 4 while keeping PA constant could lead to gains in HALE from 0.07 (CVD) to 0.34 (ACM) years. A 50% reduction in suboptimal ST (≥ 4⁠) doubled HALE gains, ranging from 0.11 to 0.63 years. Conclusions: Public health decision-makers should prioritize vulnerable populations, including older adults and individuals with inadequate PA levels.
format Artículo
author García-Witulski, Christian
author_facet García-Witulski, Christian
author_sort García-Witulski, Christian
title Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
title_short Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
title_full Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
title_fullStr Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
title_full_unstemmed Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina
title_sort comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from argentina
publisher Oxford Academic
publishDate 2025
url https://repositorio.uca.edu.ar/handle/123456789/19906
work_keys_str_mv AT garciawitulskichristian comparativeriskassessmentmodelingofcardiovascularandallcauseburdenattributabletosittingtimeandphysicalinactivityevidencefromargentina
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