Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effec...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2024
|
| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/18421 |
| Aporte de: |
| Sumario: | Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two
non-exclusive mechanisms: direct or indirect. The latter comprise those effects
mediated by the physicochemical state of the membrane bilayer, whereas direct
modulation entails the more specific regulatory effects transduced via
recognition sites on the target membrane protein. The nicotinic acetylcholine
receptor (nAChR), the paradigm member of the pentameric ligand-gated ion
channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by
both mechanisms. Reciprocally, the nAChR protein exerts influence on its
surrounding interstitial lipids. Folding, conformational equilibria, ligand binding,
ion permeation, topography, and diffusion of the nAChR are modulated by
membrane lipids. The knowledge gained from biophysical studies of this
prototypic membrane protein can be applied to other neurotransmitter
receptors and most other integral membrane proteins. |
|---|