Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids

Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effec...

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Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2024
Materias:
MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/18421
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-18421
record_format dspace
spelling I33-R139-123456789-184212025-05-21T21:27:15Z Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids Barrantes, Francisco José MEMBRANA PLASMATICA PLASMALEMA LIPIDOS DE MEMBRANA INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA PROTEINAS COLESTEROL RECEPTOR NICOTINICO DE ACETILCOLINA Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins. 2024-07-18T14:34:21Z 2024-07-18T14:34:21Z 2024 Artículo Barrantes, F.J. Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids [en línea]. Frontiers in cell and developmental biology. 2024 (11),1328875. doi: 10.3389/fcell.2023.1328875. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18421 2296-634X (online) https://repositorio.uca.edu.ar/handle/123456789/18421 10.3389/fcell.2023.1328875 eng Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media Frontiers in cell and developmental biology. 2024 (11),1328875.
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
spellingShingle MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
Barrantes, Francisco José
Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
topic_facet MEMBRANA PLASMATICA
PLASMALEMA
LIPIDOS DE MEMBRANA
INFLUENCIA DE LOS LIPIDOS EN LA MEMBRANA
PROTEINAS
COLESTEROL
RECEPTOR NICOTINICO DE ACETILCOLINA
description Abstract: Membrane lipids modulate the proteins embedded in the bilayer matrix by two non-exclusive mechanisms: direct or indirect. The latter comprise those effects mediated by the physicochemical state of the membrane bilayer, whereas direct modulation entails the more specific regulatory effects transduced via recognition sites on the target membrane protein. The nicotinic acetylcholine receptor (nAChR), the paradigm member of the pentameric ligand-gated ion channel (pLGIC) superfamily of rapid neurotransmitter receptors, is modulated by both mechanisms. Reciprocally, the nAChR protein exerts influence on its surrounding interstitial lipids. Folding, conformational equilibria, ligand binding, ion permeation, topography, and diffusion of the nAChR are modulated by membrane lipids. The knowledge gained from biophysical studies of this prototypic membrane protein can be applied to other neurotransmitter receptors and most other integral membrane proteins.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_short Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_full Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_fullStr Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_full_unstemmed Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
title_sort modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
publisher Frontiers Media
publishDate 2024
url https://repositorio.uca.edu.ar/handle/123456789/18421
work_keys_str_mv AT barrantesfranciscojose modulationofarapidneurotransmitterreceptorionchannelbymembranelipids
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