Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

Abstract: Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD both in prodromal phases and during the subsequent stages of the disea...

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Autores principales: Ciampi de Andrade, Daniel, Mylius, Veit, Pérez Lloret, Santiago, Cury, Rubens G., Bannister, Kirsty, Moisset, Xavier, Taricani Kubota, Gabriel, Finnerup, Nanna B., Bouhassira, Didier, Chaudhuri, Kallol Ray, Graven Nielsen, Thomas, Treede, Rolf Detlef
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier Science 2024
Materias:
ENFERMEDAD DE PARKINSON
RIGIDEZ
DOLOR CRONICO
DOLOR NEUROPATICO
DOLOR MUSCULOESQUELETICO
DOLOR SECUNDARIO
DOPAMINA
ESTIMULACION CEREBRAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/18382
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-18382
record_format dspace
spelling I33-R139-123456789-183822024-07-05T05:02:09Z Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them Ciampi de Andrade, Daniel Mylius, Veit Pérez Lloret, Santiago Cury, Rubens G. Bannister, Kirsty Moisset, Xavier Taricani Kubota, Gabriel Finnerup, Nanna B. Bouhassira, Didier Chaudhuri, Kallol Ray Graven Nielsen, Thomas Treede, Rolf Detlef ENFERMEDAD DE PARKINSON RIGIDEZ DOLOR CRONICO DOLOR NEUROPATICO DOLOR MUSCULOESQUELETICO DOLOR SECUNDARIO DOPAMINA ESTIMULACION CEREBRAL Abstract: Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD both in prodromal phases and during the subsequent stages of the disease, negatively affecting patient’s quality of life and function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targeting motor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD-related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or pain subtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different types of PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic. This is also in line with the International Classification of Disease-11, which acknowledges the possibility of chronic secondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinion article, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced when classifying it as a stepping stone to discuss an integrative view of the current classification approaches and how clinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeutic efforts are presented, as well as a potential framework to address them in a patient oriented manner. 2024-07-04T10:23:05Z 2024-07-04T10:23:05Z 2023 Artículo Ciampi de Andrade, D. et al. Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them [en línea]. PAIN. 2023, 164 (11). doi: 10.1097/j.pain.0000000000002968. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18382 0304-3959 (impreso) 1872-6623 (online) https://repositorio.uca.edu.ar/handle/123456789/18382 10.1097/j.pain.0000000000002968 eng Acceso abierto http://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier Science PAIN. 2023, 164 (11).
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE PARKINSON
RIGIDEZ
DOLOR CRONICO
DOLOR NEUROPATICO
DOLOR MUSCULOESQUELETICO
DOLOR SECUNDARIO
DOPAMINA
ESTIMULACION CEREBRAL
spellingShingle ENFERMEDAD DE PARKINSON
RIGIDEZ
DOLOR CRONICO
DOLOR NEUROPATICO
DOLOR MUSCULOESQUELETICO
DOLOR SECUNDARIO
DOPAMINA
ESTIMULACION CEREBRAL
Ciampi de Andrade, Daniel
Mylius, Veit
Pérez Lloret, Santiago
Cury, Rubens G.
Bannister, Kirsty
Moisset, Xavier
Taricani Kubota, Gabriel
Finnerup, Nanna B.
Bouhassira, Didier
Chaudhuri, Kallol Ray
Graven Nielsen, Thomas
Treede, Rolf Detlef
Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
topic_facet ENFERMEDAD DE PARKINSON
RIGIDEZ
DOLOR CRONICO
DOLOR NEUROPATICO
DOLOR MUSCULOESQUELETICO
DOLOR SECUNDARIO
DOPAMINA
ESTIMULACION CEREBRAL
description Abstract: Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD both in prodromal phases and during the subsequent stages of the disease, negatively affecting patient’s quality of life and function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targeting motor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD-related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or pain subtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different types of PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic. This is also in line with the International Classification of Disease-11, which acknowledges the possibility of chronic secondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinion article, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced when classifying it as a stepping stone to discuss an integrative view of the current classification approaches and how clinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeutic efforts are presented, as well as a potential framework to address them in a patient oriented manner.
format Artículo
author Ciampi de Andrade, Daniel
Mylius, Veit
Pérez Lloret, Santiago
Cury, Rubens G.
Bannister, Kirsty
Moisset, Xavier
Taricani Kubota, Gabriel
Finnerup, Nanna B.
Bouhassira, Didier
Chaudhuri, Kallol Ray
Graven Nielsen, Thomas
Treede, Rolf Detlef
author_facet Ciampi de Andrade, Daniel
Mylius, Veit
Pérez Lloret, Santiago
Cury, Rubens G.
Bannister, Kirsty
Moisset, Xavier
Taricani Kubota, Gabriel
Finnerup, Nanna B.
Bouhassira, Didier
Chaudhuri, Kallol Ray
Graven Nielsen, Thomas
Treede, Rolf Detlef
author_sort Ciampi de Andrade, Daniel
title Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
title_short Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
title_full Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
title_fullStr Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
title_full_unstemmed Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
title_sort pain in parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them
publisher Elsevier Science
publishDate 2024
url https://repositorio.uca.edu.ar/handle/123456789/18382
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