Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin

Abstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reporte...

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Autores principales: Brown, Gregory M., Karthikeyan, Ramanujam, Pandi Perumal, Seithikurippu R., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2024
Materias:
TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/18344
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
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spelling I33-R139-123456789-183442024-06-28T05:01:46Z Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin Brown, Gregory M. Karthikeyan, Ramanujam Pandi Perumal, Seithikurippu R. Cardinali, Daniel Pedro TRASTORNO DEL ESPECTRO AUTISTA COVID-19 SARS-CoV-2 MELATONINA Abstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed. 2024-06-27T11:28:24Z 2024-06-27T11:28:24Z 2021 Artículo Brown, G. M. et al. Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin [en línea]. Medical Hypotheses. 2021, 149 . doi: 10.1016/j.mehy.2021.110544. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18344 0306-9877 https://repositorio.uca.edu.ar/handle/123456789/18344 10.1016/j.mehy.2021.110544 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Medical Hypotheses. 2021, 149
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
spellingShingle TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
Brown, Gregory M.
Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
topic_facet TRASTORNO DEL ESPECTRO AUTISTA
COVID-19
SARS-CoV-2
MELATONINA
description Abstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.
format Artículo
author Brown, Gregory M.
Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
author_facet Brown, Gregory M.
Karthikeyan, Ramanujam
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
author_sort Brown, Gregory M.
title Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_short Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_full Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_fullStr Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_full_unstemmed Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin
title_sort autism spectrum disorder patients may be susceptible to covid-19 disease due to deficiency in melatonin
publisher Elsevier
publishDate 2024
url https://repositorio.uca.edu.ar/handle/123456789/18344
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