Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease

Este artículo pertenece a un número especial llamado "New Discoveries in Drug Targets and Delivery for Alzheimer’s Disease", que se puede consultar desde el siguiente enlace: https://www.mdpi.com/journal/pharmaceutics/special_issues/30TR5812B9

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Detalles Bibliográficos
Autores principales: Colavitta, María Florencia, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: MDPI 2024
Materias:
ENFERMEDAD DE ALZHEIMER
COGNICION
NEUROPLASTICIDAD
NEUROTRANSMISORES
POTENCIADOR DE LARGO PLAZO
DETERIORO COGNITIVO
DEMENCIA
ENFERMEDADES NEURODEGENERATIVAS
NEUROINFLAMACION
TERAPIAS
Acceso en línea:https://www.mdpi.com/1999-4923/15/8/2052
https://repositorio.uca.edu.ar/handle/123456789/18318
https://doi.org/10.3390/pharmaceutics15082052
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-18318
record_format dspace
spelling I33-R139-123456789-183182024-06-20T05:01:29Z Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease Colavitta, María Florencia Barrantes, Francisco José ENFERMEDAD DE ALZHEIMER COGNICION NEUROPLASTICIDAD NEUROTRANSMISORES POTENCIADOR DE LARGO PLAZO DETERIORO COGNITIVO DEMENCIA ENFERMEDADES NEURODEGENERATIVAS NEUROINFLAMACION TERAPIAS Este artículo pertenece a un número especial llamado "New Discoveries in Drug Targets and Delivery for Alzheimer’s Disease", que se puede consultar desde el siguiente enlace: https://www.mdpi.com/journal/pharmaceutics/special_issues/30TR5812B9 Abstract: Alzheimer disease (AD) is the most prevalent form of dementia among elderly people. Owing to its varied and multicausal etiopathology, intervention strategies have been highly diverse. Despite ongoing advances in the field, efficient therapies to mitigate AD symptoms or delay their progression are still of limited scope. Neuroplasticity, in broad terms the ability of the brain to modify its structure in response to external stimulation or damage, has received growing attention as a possible therapeutic target, since the disruption of plastic mechanisms in the brain appear to correlate with various forms of cognitive impairment present in AD patients. Several pre-clinical and clinical studies have attempted to enhance neuroplasticity via different mechanisms, for example, regulating glucose or lipid metabolism, targeting the activity of neurotransmitter systems, or addressing neuroinflammation. In this review, we first describe several structural and functional aspects of neuroplasticity. We then focus on the current status of pharmacological approaches to AD stemming from clinical trials targeting neuroplastic mechanisms in AD patients. This is followed by an analysis of analogous pharmacological interventions in animal models, according to their mechanisms of action. 2024-06-19T17:47:34Z 2024-06-19T17:47:34Z 2023 Artículo Colavitta, M.F.; Barrantes, F.J. Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease [En línea]. Pharmaceutics 2023, vol. 15, N° 18, 2052. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18318 1999-4923 (online) https://www.mdpi.com/1999-4923/15/8/2052 https://repositorio.uca.edu.ar/handle/123456789/18318 https://doi.org/10.3390/pharmaceutics15082052 eng Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ application/pdf MDPI Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE ALZHEIMER
COGNICION
NEUROPLASTICIDAD
NEUROTRANSMISORES
POTENCIADOR DE LARGO PLAZO
DETERIORO COGNITIVO
DEMENCIA
ENFERMEDADES NEURODEGENERATIVAS
NEUROINFLAMACION
TERAPIAS
spellingShingle ENFERMEDAD DE ALZHEIMER
COGNICION
NEUROPLASTICIDAD
NEUROTRANSMISORES
POTENCIADOR DE LARGO PLAZO
DETERIORO COGNITIVO
DEMENCIA
ENFERMEDADES NEURODEGENERATIVAS
NEUROINFLAMACION
TERAPIAS
Colavitta, María Florencia
Barrantes, Francisco José
Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
topic_facet ENFERMEDAD DE ALZHEIMER
COGNICION
NEUROPLASTICIDAD
NEUROTRANSMISORES
POTENCIADOR DE LARGO PLAZO
DETERIORO COGNITIVO
DEMENCIA
ENFERMEDADES NEURODEGENERATIVAS
NEUROINFLAMACION
TERAPIAS
description Este artículo pertenece a un número especial llamado "New Discoveries in Drug Targets and Delivery for Alzheimer’s Disease", que se puede consultar desde el siguiente enlace: https://www.mdpi.com/journal/pharmaceutics/special_issues/30TR5812B9
format Artículo
author Colavitta, María Florencia
Barrantes, Francisco José
author_facet Colavitta, María Florencia
Barrantes, Francisco José
author_sort Colavitta, María Florencia
title Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
title_short Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
title_full Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
title_fullStr Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
title_full_unstemmed Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
title_sort therapeutic strategies aimed at improving neuroplasticity in alzheimer disease
publisher MDPI
publishDate 2024
url https://www.mdpi.com/1999-4923/15/8/2052
https://repositorio.uca.edu.ar/handle/123456789/18318
https://doi.org/10.3390/pharmaceutics15082052
work_keys_str_mv AT colavittamariaflorencia therapeuticstrategiesaimedatimprovingneuroplasticityinalzheimerdisease
AT barrantesfranciscojose therapeuticstrategiesaimedatimprovingneuroplasticityinalzheimerdisease
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