Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (...
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| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2023
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/17438 |
| Aporte de: |
| Sumario: | Abstract: Introduction: The circadian system regulates various physiological processes
such as sleep-wake cycles, hormone secretion, metabolism, and the reaction
to both natural and drug-based rewards. Chronic disruption of the circadian
system caused by unsteady synchronization with light-dark (LD) schedules, such
as advancing chronic jet lag (CJL), leads to adverse physiological effects and
pathologies, and is linked with changes in mood and depressive behaviors in
humans and rodent models.
Methods: C57BL/6J male mice were subjected to circadian disruption through
phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were
used as controls. After 8 weeks under these conditions, a battery of behavioral
tests was performed to assess if mood-related behaviors were affected.
Results: Compared to controls under 24 h LD cycles, mice under CJL presented
desynchronization of activity-rest rhythms that led to several behavioral
impairments, including a decrease in motivation for food reward, and an
increase in anxiety, anhedonia, and depressive-like behavior.
Conclusion: Chronic circadian disruption, caused by an experimental CJL
protocol, affects mood-related and reward-related behaviors in mice.
Understanding the importance of the circadian system and its potential role for
disruption due to CJL is important for maintaining good health and well-being. |
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