Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice

Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (...

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Autores principales: Acosta, Julieta, Crespo, Manuel T., Plano, Santiago Andrés, Golombek, Diego A., Chiesa, Juan José, Agostino, Patricia V.
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2023
Materias:
RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/17438
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-17438
record_format dspace
spelling I33-R139-123456789-174382023-11-23T18:15:09Z Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice Acosta, Julieta Crespo, Manuel T. Plano, Santiago Andrés Golombek, Diego A. Chiesa, Juan José Agostino, Patricia V. RITMO CIRCADIANO SUEÑO TRASTORNOS DEL SUEÑO DEPRESION TRASTONOS CRONOBIOLOGICOS ESTADO DE ANIMO MOTIVACION Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being. 2023-11-14T10:26:39Z 2023-11-14T10:26:39Z 2023 Artículo Acosta, J., Crespo, M. T., Plano, S. A., Golombek, D. A., Chiesa, J. J., Agostino, P. V. Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice [en línea]. En: Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134. doi: 10.3389/fphys.2023.1225134. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17438 1664-042X https://repositorio.uca.edu.ar/handle/123456789/17438 10.3389/fphys.2023.1225134 37745237 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Acosta, J. et al. Chronic jet lag reduces motivation and affects other moodrelated behaviors in male mice. Frontiers in Physiology. 2023, 14:1225134
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
spellingShingle RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
Acosta, Julieta
Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
topic_facet RITMO CIRCADIANO
SUEÑO
TRASTORNOS DEL SUEÑO
DEPRESION
TRASTONOS CRONOBIOLOGICOS
ESTADO DE ANIMO
MOTIVACION
description Abstract: Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
format Artículo
author Acosta, Julieta
Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
author_facet Acosta, Julieta
Crespo, Manuel T.
Plano, Santiago Andrés
Golombek, Diego A.
Chiesa, Juan José
Agostino, Patricia V.
author_sort Acosta, Julieta
title Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_short Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_fullStr Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_full_unstemmed Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
title_sort chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
publisher Frontiers Media
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/17438
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