The epidemiology and etiopathogenesis of graves’ disease

Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4)...

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Autores principales: Saban, Melina, Curriá, Marina Inés, Romeo, Horacio, Barreiro Arcos, María Laura
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Nova Science 2023
Materias:
ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16519
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16519
record_format dspace
spelling I33-R139-123456789-165192023-06-27T21:23:47Z The epidemiology and etiopathogenesis of graves’ disease Saban, Melina Curriá, Marina Inés Romeo, Horacio Barreiro Arcos, María Laura ENFERMEDAD DE GRAVES AUTOINMUNIDAD GLANDULA TIROIDES HORMONA TIROIDEA OFTALMOPATIA DE GRAVES EPIDEMIOLOGIA Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD. 2023-06-14T11:04:07Z 2023-06-14T11:04:07Z 2023 Parte de libro Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519 9798886976366 https://repositorio.uca.edu.ar/handle/123456789/16519 10.52305/HCEE6098 eng Acceso restringido Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nova Science Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
spellingShingle ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
Saban, Melina
Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
The epidemiology and etiopathogenesis of graves’ disease
topic_facet ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
description Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD.
format Parte de libro
author Saban, Melina
Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
author_facet Saban, Melina
Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
author_sort Saban, Melina
title The epidemiology and etiopathogenesis of graves’ disease
title_short The epidemiology and etiopathogenesis of graves’ disease
title_full The epidemiology and etiopathogenesis of graves’ disease
title_fullStr The epidemiology and etiopathogenesis of graves’ disease
title_full_unstemmed The epidemiology and etiopathogenesis of graves’ disease
title_sort epidemiology and etiopathogenesis of graves’ disease
publisher Nova Science
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16519
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