Melatonin and healthy aging

Abstract: Preservation of a robust circadian rhythmicity (particulsarly of the sleep/wake cycle), a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging comes along with circadian alteration, e.g. a disrupted sleep and inflammation, that leads to metabolic disord...

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Autor principal: Cardinali, Daniel Pedro
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Elsevier 2023
Materias:
MELATONINA
ENVEJECIMIENTO
SALUD
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16499
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16499
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spelling I33-R139-123456789-164992023-11-23T17:57:20Z Melatonin and healthy aging Cardinali, Daniel Pedro MELATONINA ENVEJECIMIENTO SALUD Abstract: Preservation of a robust circadian rhythmicity (particulsarly of the sleep/wake cycle), a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging comes along with circadian alteration, e.g. a disrupted sleep and inflammation, that leads to metabolic disorders. In turn, sleep cycle disturbances cause numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep disruption impairs several functions, among them, the clearance of waste molecules. The decrease of plasma melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, plays a particular role as far as the endocrine sequels of aging. Every day, the late afternoon/nocturnal increase of melatonin synchronizes both the central circadian pacemaker located in the hypothalamic suprachiasmatic nuclei as well as myriads of peripheral cellular circadian clocks. This is called the “chronobiotic effect” of melatonin, the methoxyindole being the prototype of the endogenous family of chronobiotic agents. In addition, melatonin exerts a significant cytoprotective action by buffering free radicals and reversing inflammation via down regulation of proinflammatory cytokines, suppression of low degree inflammation and prevention of insulin resistance. Because of these properties melatonin has been advocated to be a potential therapeutic tool in COVID 19 pandemic. Melatonin administration to aged animals counteracts a significant number of senescence-related changes. In humans, melatonin is effective both as a chronobiotic and a cytoprotective agent to maintain a healthy aging. Circulating melatonin levels are consistently reduced in the metabolic syndrome, ischemic and non-ischemic cardiovascular diseases and neurodegenerative disorders like the Alzheimer's and Parkinson's diseases. The potential therapeutic value of melatonin has been suggested by a limited number of clinical trials generally employing melatonin in the 2–10 mg/day range. However, from animal studies the cytoprotective effects of melatonin need higher doses to become apparent (i.e. in the 100 mg/day range). Hence, controlled studies employing melatonin doses in this range are urgently needed. 2023-06-12T15:17:46Z 2023-06-12T15:17:46Z 2021 Parte de libro Cardinali, D.P. Melatonin and healthy aging [en línea]. En: Litwack, G. (eds.). Vitamins and Hormones. Elsevier, 2021 doi:10.1016/bs.vh.2020.12.004 978-0-323-85548-8 0083-6729 https://repositorio.uca.edu.ar/handle/123456789/16499 10.1016/bs.vh.2020.12.004 33706965 eng Acceso abierto. 24 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Litwack, G. (eds.). Vitamins and Hormones. Elsevier, 2021
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
ENVEJECIMIENTO
SALUD
spellingShingle MELATONINA
ENVEJECIMIENTO
SALUD
Cardinali, Daniel Pedro
Melatonin and healthy aging
topic_facet MELATONINA
ENVEJECIMIENTO
SALUD
description Abstract: Preservation of a robust circadian rhythmicity (particulsarly of the sleep/wake cycle), a proper nutrition and adequate physical exercise are key elements for healthy aging. Aging comes along with circadian alteration, e.g. a disrupted sleep and inflammation, that leads to metabolic disorders. In turn, sleep cycle disturbances cause numerous pathophysiological changes that accelerates the aging process. In the central nervous system, sleep disruption impairs several functions, among them, the clearance of waste molecules. The decrease of plasma melatonin, a molecule of unusual phylogenetic conservation present in all known aerobic organisms, plays a particular role as far as the endocrine sequels of aging. Every day, the late afternoon/nocturnal increase of melatonin synchronizes both the central circadian pacemaker located in the hypothalamic suprachiasmatic nuclei as well as myriads of peripheral cellular circadian clocks. This is called the “chronobiotic effect” of melatonin, the methoxyindole being the prototype of the endogenous family of chronobiotic agents. In addition, melatonin exerts a significant cytoprotective action by buffering free radicals and reversing inflammation via down regulation of proinflammatory cytokines, suppression of low degree inflammation and prevention of insulin resistance. Because of these properties melatonin has been advocated to be a potential therapeutic tool in COVID 19 pandemic. Melatonin administration to aged animals counteracts a significant number of senescence-related changes. In humans, melatonin is effective both as a chronobiotic and a cytoprotective agent to maintain a healthy aging. Circulating melatonin levels are consistently reduced in the metabolic syndrome, ischemic and non-ischemic cardiovascular diseases and neurodegenerative disorders like the Alzheimer's and Parkinson's diseases. The potential therapeutic value of melatonin has been suggested by a limited number of clinical trials generally employing melatonin in the 2–10 mg/day range. However, from animal studies the cytoprotective effects of melatonin need higher doses to become apparent (i.e. in the 100 mg/day range). Hence, controlled studies employing melatonin doses in this range are urgently needed.
format Parte de libro
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_sort Cardinali, Daniel Pedro
title Melatonin and healthy aging
title_short Melatonin and healthy aging
title_full Melatonin and healthy aging
title_fullStr Melatonin and healthy aging
title_full_unstemmed Melatonin and healthy aging
title_sort melatonin and healthy aging
publisher Elsevier
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16499
work_keys_str_mv AT cardinalidanielpedro melatoninandhealthyaging
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