Chronotherapy

Abstract: The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Chronotherapy is referred to and practiced in two different ways: (1) to alter the sleep–wake rhythms of patients to improve the sequels of several pathologies; (2) to ta...

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Autores principales: Cardinali, Daniel Pedro, Brown, Gregory M., Pandi Perumal, Seithikurippu R.
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Elsevier 2023
Materias:
CRONOTERAPIA
TRATAMIENTO MEDICO
RITMO CIRCADIANO
SUEÑO
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16497
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16497
record_format dspace
spelling I33-R139-123456789-164972023-11-23T17:55:32Z Chronotherapy Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. CRONOTERAPIA TRATAMIENTO MEDICO RITMO CIRCADIANO SUEÑO MELATONINA Abstract: The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Chronotherapy is referred to and practiced in two different ways: (1) to alter the sleep–wake rhythms of patients to improve the sequels of several pathologies; (2) to take into account the circadian rhythms of patients to improve therapeutics. Even minor dysfunction of the biological clock can greatly affect sleep/wake physiology causing excessive diurnal somnolence, increase in sleep onset latency, phase delays or advances in sleep onset, frequent night awakenings, reduced sleep efficiency, delayed and shortened rapid eye movement sleep, or increased periodic leg movements. Chronotherapy aims to restore the proper circadian pattern of the sleep–wake cycle, through adequate sleep hygiene, timed light exposure, and the use of chronobiotic medications, such as melatonin, that affect the output phase of circadian rhythms, thus controlling the clock. Concerning the second use of chronotherapy, therapeutic outcomes as diverse as the survival after open-heart surgery or the efficacy and tolerance to chemotherapy vary according to the time of day. However, humans are heterogeneous concerning the timing of their internal clocks. Not only different chronotypes exist but also the endogenous human circadian period (τ) is not a stable trait as it depends on many internal and external factors. If any scheduled therapeutic intervention is going to be optimized, a tool is needed for simple diagnostic and objectively measurement of an individual's internal time at any given time. Methodologic advances like the use of single-sample gene expression and metabolomics are discussed. 2023-06-12T14:35:39Z 2023-06-12T14:35:39Z 2021 Parte de libro Cardinali, D.P., Brown, G.M., Pandi Perumal, S.R. Chronotherapy [en línea]. En: Dick F. Swaab, F.K., Lucassen, P.J., Salehi, A., Buijs, R.M., (eds.). Handbook of Clinical Neurology. Vol. 179. Elsevier, 2021 doi:10.1016/B978-0-12-819975-6.00023-6 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16497 0072-9752 https://repositorio.uca.edu.ar/handle/123456789/16497 9780128199756 10.1016/B978-0-12-819975-6.00023-6 34225975 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Dick F. Swaab, F.K., Lucassen, P.J., Salehi, A., Buijs, R.M., (eds.). Handbook of Clinical Neurology. Vol. 179. Elsevier, 2021
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CRONOTERAPIA
TRATAMIENTO MEDICO
RITMO CIRCADIANO
SUEÑO
MELATONINA
spellingShingle CRONOTERAPIA
TRATAMIENTO MEDICO
RITMO CIRCADIANO
SUEÑO
MELATONINA
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Chronotherapy
topic_facet CRONOTERAPIA
TRATAMIENTO MEDICO
RITMO CIRCADIANO
SUEÑO
MELATONINA
description Abstract: The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Chronotherapy is referred to and practiced in two different ways: (1) to alter the sleep–wake rhythms of patients to improve the sequels of several pathologies; (2) to take into account the circadian rhythms of patients to improve therapeutics. Even minor dysfunction of the biological clock can greatly affect sleep/wake physiology causing excessive diurnal somnolence, increase in sleep onset latency, phase delays or advances in sleep onset, frequent night awakenings, reduced sleep efficiency, delayed and shortened rapid eye movement sleep, or increased periodic leg movements. Chronotherapy aims to restore the proper circadian pattern of the sleep–wake cycle, through adequate sleep hygiene, timed light exposure, and the use of chronobiotic medications, such as melatonin, that affect the output phase of circadian rhythms, thus controlling the clock. Concerning the second use of chronotherapy, therapeutic outcomes as diverse as the survival after open-heart surgery or the efficacy and tolerance to chemotherapy vary according to the time of day. However, humans are heterogeneous concerning the timing of their internal clocks. Not only different chronotypes exist but also the endogenous human circadian period (τ) is not a stable trait as it depends on many internal and external factors. If any scheduled therapeutic intervention is going to be optimized, a tool is needed for simple diagnostic and objectively measurement of an individual's internal time at any given time. Methodologic advances like the use of single-sample gene expression and metabolomics are discussed.
format Parte de libro
author Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_facet Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_sort Cardinali, Daniel Pedro
title Chronotherapy
title_short Chronotherapy
title_full Chronotherapy
title_fullStr Chronotherapy
title_full_unstemmed Chronotherapy
title_sort chronotherapy
publisher Elsevier
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16497
work_keys_str_mv AT cardinalidanielpedro chronotherapy
AT browngregorym chronotherapy
AT pandiperumalseithikurippur chronotherapy
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