Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults
Abstract Background: COVID-19 has affected more than 380 million people. Infections may result in long term sequelae, including neuropsychiatric symptoms. In older adults COVID-19 sequelae resemble early Alzheimer’s disease, and may share risk factors and blood biomarkers with it. The Alzheimer’...
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Alzheimer’s Association
2023
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/16493 |
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I33-R139-123456789-164932023-06-09T13:45:44Z Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults Gonzalez Aleman, Gabriela Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina Rangeo, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Vaca, Fabiana Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de COVID-19 ADULTOS MAYORES ENFERMEDAD DE ALZHEIMER DISFUNCION OLFATORIA Abstract Background: COVID-19 has affected more than 380 million people. Infections may result in long term sequelae, including neuropsychiatric symptoms. In older adults COVID-19 sequelae resemble early Alzheimer’s disease, and may share risk factors and blood biomarkers with it. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with exposure to COVID-19. We present one year data in a prospective cohort from Argentina. Method: Participants (n = 766) are older adults (≥60 years) recruited from the provincial health registry containing all SARS-CoV-2 testing data. We randomly invite older adults stratified by PCR COVID-19 testing status regardless of symptom severity, between 3 and 6 months after recovery. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale (CDR); neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. Result: We assessed 88.4% infected participants and 11.6 % controls. Education is 10.36 ± 5.6 years and age is 66.9 ± 6.14 years. Level of care during COVID-19 is described in Figure 1. Normalized cognitive Z-scores categorize the cohort in 3 groups with decreased performance compared to normal cognition: memory only impairment (Single-domain,11.7%); impairment in attention+executive function without memory impairment (Two-domain, 8.3%); and multiple domain impairment (Multiple domain,11.6%). Logistic regression showed that severity of anosmia, but not clinical status, significantly predicts cognitive impairment. No controls had olfactory dysfunction. Cognitive impairment is defined as Z-scores below (- 2) (Table 1). Clinical assessment with SCAN revealed functional memory impairment in two thirds of infected patients (CDR ≥ 1), which was severe in half of them. Phone-based follow up at 1 year revealed high adherence (4 participants declined). Five were deceased at follow up. Rates of re-infection (between 10 and 23%) were not affected by the vaccination schedule (Table 2). Conclusion: The longitudinal cohort had very high adherence. Persistent cognitive and functional impairment after SARS-CoV-2 infection is predicted by persistent anosmia but not by the severity of the initial COVID-19 disease. 2023-06-08T12:37:57Z 2023-06-08T12:37:57Z 2022 Artículo Gonzalez Aleman, G. et al. Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults [en línea]. Alzheimers Dement. 2022, 18 (7). doi: 10.1002/alz.066868. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16493 1552-5279 https://repositorio.uca.edu.ar/handle/123456789/16493 10.1002/alz.066868 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Argentina Alzheimer’s Association Wiley Alzheimers Dement Vol.18, No.7, 2022 |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
COVID-19 ADULTOS MAYORES ENFERMEDAD DE ALZHEIMER DISFUNCION OLFATORIA |
| spellingShingle |
COVID-19 ADULTOS MAYORES ENFERMEDAD DE ALZHEIMER DISFUNCION OLFATORIA Gonzalez Aleman, Gabriela Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina Rangeo, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Vaca, Fabiana Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| topic_facet |
COVID-19 ADULTOS MAYORES ENFERMEDAD DE ALZHEIMER DISFUNCION OLFATORIA |
| description |
Abstract
Background: COVID-19 has affected more than 380 million people. Infections may
result in long term sequelae, including neuropsychiatric symptoms. In older adults
COVID-19 sequelae resemble early Alzheimer’s disease, and may share risk factors
and blood biomarkers with it. The Alzheimer’s Association Consortium on Chronic
Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and
longitudinally follow up cohorts of older adults with exposure to COVID-19. We
present one year data in a prospective cohort from Argentina.
Method: Participants (n = 766) are older adults (≥60 years) recruited from the provincial health registry containing all SARS-CoV-2 testing data. We randomly invite older
adults stratified by PCR COVID-19 testing status regardless of symptom severity,
between 3 and 6 months after recovery. Assessment includes interview with the
Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia
Rating scale (CDR); neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function,
coordination and gait.
Result: We assessed 88.4% infected participants and 11.6 % controls. Education is 10.36 ± 5.6 years and age is 66.9 ± 6.14 years. Level of care during COVID-19 is described in Figure 1. Normalized cognitive Z-scores categorize the
cohort in 3 groups with decreased performance compared to normal cognition:
memory only impairment (Single-domain,11.7%); impairment in attention+executive
function without memory impairment (Two-domain, 8.3%); and multiple domain
impairment (Multiple domain,11.6%). Logistic regression showed that severity of anosmia, but not clinical status, significantly predicts cognitive impairment. No controls had
olfactory dysfunction. Cognitive impairment is defined as Z-scores below (- 2) (Table 1).
Clinical assessment with SCAN revealed functional memory impairment in two thirds
of infected patients (CDR ≥ 1), which was severe in half of them. Phone-based follow
up at 1 year revealed high adherence (4 participants declined). Five were deceased
at follow up. Rates of re-infection (between 10 and 23%) were not affected by the
vaccination schedule (Table 2).
Conclusion: The longitudinal cohort had very high adherence. Persistent cognitive and
functional impairment after SARS-CoV-2 infection is predicted by persistent anosmia
but not by the severity of the initial COVID-19 disease. |
| format |
Artículo |
| author |
Gonzalez Aleman, Gabriela Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina Rangeo, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Vaca, Fabiana Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de |
| author_facet |
Gonzalez Aleman, Gabriela Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina Rangeo, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Vaca, Fabiana Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de |
| author_sort |
Gonzalez Aleman, Gabriela |
| title |
Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| title_short |
Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| title_full |
Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| title_fullStr |
Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| title_full_unstemmed |
Olfactory dysfunction but not COVID-19 severity predicts severity of cognitive sequelae following SARS-CoV-2 infection in Amerindian older adults |
| title_sort |
olfactory dysfunction but not covid-19 severity predicts severity of cognitive sequelae following sars-cov-2 infection in amerindian older adults |
| publisher |
Alzheimer’s Association |
| publishDate |
2023 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/16493 |
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