Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease
Abstract: With the aging of the world population, there has been a notable increase in the incidence of Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly. Several studies have reported a delay in the onset of AD symptoms and age-related cognitive dysfunct...
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| Autores principales: | , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2023
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/16478 |
| Aporte de: |
| Sumario: | Abstract: With the aging of the world population, there has been a
notable increase in the incidence of Alzheimer disease (AD),
the most prevalent neurodegenerative disease affecting the
elderly. Several studies have reported a delay in the onset of
AD symptoms and age-related cognitive dysfunction upon
changes to a healthier lifestyle. These positive adjustments
find support in the cognitive reserve hypothesis, which holds
that the ability to defer disease inception and protect cognitive
performance is related to healthier lifestyle habits such as
cognitive and physical activity, social engagement, and sensorial
stimulation. These lifestyle habits can be compounded under
the umbrella of the environmental enrichment (EE) paradigm.
The mechanisms underlying EE’s capacity to modulate disease
expression remain unclear. Since ethical and methodological
considerations rule out direct analysis of such changes in the
human brain, researchers have resorted to animal models to
carry out in-depth characterizations of post-EE structural and
functional brain modifications using a variety of behavioral,
electrophysiological, genetic, biochemical, and biophysical
approaches. Moreover, given the shorter lifespan of animals
compared to humans, it is possible to address the effects of
aging in control and AD models. In this review we analyze
and classify EE data from studies using AD murine models
and compare the setup variables employed. We also delve into
various aspects of neuroplasticity, under the posit that this
property is the key mechanistic process underlying the benefits
of EE in both animal and human subjects. |
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