Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease
Abstract: With the aging of the world population, there has been a notable increase in the incidence of Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly. Several studies have reported a delay in the onset of AD symptoms and age-related cognitive dysfunct...
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2023
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/16478 |
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I33-R139-123456789-164782023-11-23T17:51:44Z Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease Colavitta, María Florencia Grasso, Lina Barrantes, Francisco José ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS CONDUCTA DISFUNCION COGNITIVA HABITOS SALUDABLES NEUROPLASTICIDAD Abstract: With the aging of the world population, there has been a notable increase in the incidence of Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly. Several studies have reported a delay in the onset of AD symptoms and age-related cognitive dysfunction upon changes to a healthier lifestyle. These positive adjustments find support in the cognitive reserve hypothesis, which holds that the ability to defer disease inception and protect cognitive performance is related to healthier lifestyle habits such as cognitive and physical activity, social engagement, and sensorial stimulation. These lifestyle habits can be compounded under the umbrella of the environmental enrichment (EE) paradigm. The mechanisms underlying EE’s capacity to modulate disease expression remain unclear. Since ethical and methodological considerations rule out direct analysis of such changes in the human brain, researchers have resorted to animal models to carry out in-depth characterizations of post-EE structural and functional brain modifications using a variety of behavioral, electrophysiological, genetic, biochemical, and biophysical approaches. Moreover, given the shorter lifespan of animals compared to humans, it is possible to address the effects of aging in control and AD models. In this review we analyze and classify EE data from studies using AD murine models and compare the setup variables employed. We also delve into various aspects of neuroplasticity, under the posit that this property is the key mechanistic process underlying the benefits of EE in both animal and human subjects. 2023-06-06T14:24:38Z 2023-06-06T14:24:38Z 2023 Artículo Colavitta, M. F., Grasso, L., Barrantes, F. J. Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease [en línea]. The Journal of Prevention of Alzheimer's Disease. 2023, 10. doi: 10.14283/jpad.2023.5. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16478 2426-0266 (online) https://repositorio.uca.edu.ar/handle/123456789/16478 10.14283/jpad.2023.5 36946456 eng Acceso restringido http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer The Journal of Prevention of Alzheimer's Disease. 2023, 10 |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS CONDUCTA DISFUNCION COGNITIVA HABITOS SALUDABLES NEUROPLASTICIDAD |
| spellingShingle |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS CONDUCTA DISFUNCION COGNITIVA HABITOS SALUDABLES NEUROPLASTICIDAD Colavitta, María Florencia Grasso, Lina Barrantes, Francisco José Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| topic_facet |
ENFERMEDAD DE ALZHEIMER ENFERMEDADES NEURODEGENERATIVAS CONDUCTA DISFUNCION COGNITIVA HABITOS SALUDABLES NEUROPLASTICIDAD |
| description |
Abstract: With the aging of the world population, there has been a
notable increase in the incidence of Alzheimer disease (AD),
the most prevalent neurodegenerative disease affecting the
elderly. Several studies have reported a delay in the onset of
AD symptoms and age-related cognitive dysfunction upon
changes to a healthier lifestyle. These positive adjustments
find support in the cognitive reserve hypothesis, which holds
that the ability to defer disease inception and protect cognitive
performance is related to healthier lifestyle habits such as
cognitive and physical activity, social engagement, and sensorial
stimulation. These lifestyle habits can be compounded under
the umbrella of the environmental enrichment (EE) paradigm.
The mechanisms underlying EE’s capacity to modulate disease
expression remain unclear. Since ethical and methodological
considerations rule out direct analysis of such changes in the
human brain, researchers have resorted to animal models to
carry out in-depth characterizations of post-EE structural and
functional brain modifications using a variety of behavioral,
electrophysiological, genetic, biochemical, and biophysical
approaches. Moreover, given the shorter lifespan of animals
compared to humans, it is possible to address the effects of
aging in control and AD models. In this review we analyze
and classify EE data from studies using AD murine models
and compare the setup variables employed. We also delve into
various aspects of neuroplasticity, under the posit that this
property is the key mechanistic process underlying the benefits
of EE in both animal and human subjects. |
| format |
Artículo |
| author |
Colavitta, María Florencia Grasso, Lina Barrantes, Francisco José |
| author_facet |
Colavitta, María Florencia Grasso, Lina Barrantes, Francisco José |
| author_sort |
Colavitta, María Florencia |
| title |
Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| title_short |
Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| title_full |
Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| title_fullStr |
Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| title_full_unstemmed |
Environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| title_sort |
environmental enrichment in murine models and its translation to human factors improving conditions in alzheimer disease |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/16478 |
| work_keys_str_mv |
AT colavittamariaflorencia environmentalenrichmentinmurinemodelsanditstranslationtohumanfactorsimprovingconditionsinalzheimerdisease AT grassolina environmentalenrichmentinmurinemodelsanditstranslationtohumanfactorsimprovingconditionsinalzheimerdisease AT barrantesfranciscojose environmentalenrichmentinmurinemodelsanditstranslationtohumanfactorsimprovingconditionsinalzheimerdisease |
| _version_ |
1807949179261026304 |