An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Pat...
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Autores principales: | , , , , , , , |
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Formato: | Artículo |
Lenguaje: | Inglés |
Publicado: |
Dove Press
2023
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Materias: | |
Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/16425 |
Aporte de: |
Sumario: | Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive
impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on
this association.
Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this
study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake
autonomic activity.
Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects.
Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than
controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated
with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI
patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004).
Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages
of dementia as well as a potential protective effect of exogenous melatonin in this population. |
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