An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor

Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Pat...

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Autores principales: Abulafia, Carolina Andrea, Vidal, María F., Olivar, Natividad, Odzak, Andrea, Brusco, Ignacio, Guinjoan, Salvador M., Cardinali, Daniel Pedro, Vigo, Daniel E.
Formato: Artículo
Lenguaje:Inglés
Publicado: Dove Press 2023
Materias:
DETERIORO COGNITIVO LEVE
MELATONINA
ACTIGRAFIA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16425
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16425
record_format dspace
spelling I33-R139-123456789-164252023-06-26T18:14:54Z An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor Abulafia, Carolina Andrea Vidal, María F. Olivar, Natividad Odzak, Andrea Brusco, Ignacio Guinjoan, Salvador M. Cardinali, Daniel Pedro Vigo, Daniel E. DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population. 2023-05-30T12:06:59Z 2023-05-30T12:06:59Z 2023 Artículo Abulafia, C. A. et al. An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor [en línea]. Clinical Interventions in Aging. 2023, 18. doi: 10.2147/CIA.S394749. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16425 1178-1998 https://repositorio.uca.edu.ar/handle/123456789/16425 10.2147/CIA.S394749 eng Acceso abierto Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Dove Press Clinical Interventions in Aging. Vol.18, 2023
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic DETERIORO COGNITIVO LEVE
MELATONINA
ACTIGRAFIA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
spellingShingle DETERIORO COGNITIVO LEVE
MELATONINA
ACTIGRAFIA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
Abulafia, Carolina Andrea
Vidal, María F.
Olivar, Natividad
Odzak, Andrea
Brusco, Ignacio
Guinjoan, Salvador M.
Cardinali, Daniel Pedro
Vigo, Daniel E.
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
topic_facet DETERIORO COGNITIVO LEVE
MELATONINA
ACTIGRAFIA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
description Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population.
format Artículo
author Abulafia, Carolina Andrea
Vidal, María F.
Olivar, Natividad
Odzak, Andrea
Brusco, Ignacio
Guinjoan, Salvador M.
Cardinali, Daniel Pedro
Vigo, Daniel E.
author_facet Abulafia, Carolina Andrea
Vidal, María F.
Olivar, Natividad
Odzak, Andrea
Brusco, Ignacio
Guinjoan, Salvador M.
Cardinali, Daniel Pedro
Vigo, Daniel E.
author_sort Abulafia, Carolina Andrea
title An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
title_short An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
title_full An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
title_fullStr An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
title_full_unstemmed An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
title_sort exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
publisher Dove Press
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16425
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