A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease

Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH w...

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Autores principales: Loureiro, Débora, Bilbao, Rodrigo, Bordet, Sofía, Grasso, Lina, Otero Losada, Matilde, Capani, Francisco, Ponzo, Osvaldo J., Pérez Lloret, Santiago
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2023
Materias:
DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16231
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Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16231
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spelling I33-R139-123456789-162312023-04-26T20:27:49Z A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease Loureiro, Débora Bilbao, Rodrigo Bordet, Sofía Grasso, Lina Otero Losada, Matilde Capani, Francisco Ponzo, Osvaldo J. Pérez Lloret, Santiago DETERIORO COGNITIVO LEVE HIPOTENSION ORTOSTATICA HIPERTENSION ENFERMEDAD DE PARKINSON DEMENCIA SEXO Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension. 2023-04-18T13:12:10Z 2023-04-18T13:12:10Z 2023 Artículo Pérez Lloret, S. et al. A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease [en línea]. Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4). doi: 10.1007/s10072-022-06537-3. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16231 1590-1874 (impreso) 1590-3478 (online) https://repositorio.uca.edu.ar/handle/123456789/16231 10.1007/s10072-022-06537-3 eng Acceso abierto. 12 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Postprint de artículo publicado en Ciencias Neurológicas. 2023, 44 (4)
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
spellingShingle DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
Loureiro, Débora
Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
topic_facet DETERIORO COGNITIVO LEVE
HIPOTENSION ORTOSTATICA
HIPERTENSION
ENFERMEDAD DE PARKINSON
DEMENCIA
SEXO
description Abstract: Background. Cognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a risk factor for cognitive impairment. Objective. We conducted a Systematic Review and Meta-analysis to examine the relationship between OH with PD-associated Minimal Cognitive Impairment (PD-MCI) and Dementia (PDD) and assess the mitigating effects of potential confounding factors. Methods. Observational studies published in English, Spanish, French, or Portuguese up to January 2022 were searched for in PubMed, EBSCO, and SciELO databases. The primary aim of this study was to revise the association between OH with PD-MCI and PDD. Alongside, we assessed OH as related to cognitive rating scales. Fixed and random models were fitted. Meta-regression was used to assess the mitigating effects of confounding variables. Results. We identified 18 studies that reported OH association with PDD or PD-MCI, 15 of them reporting OH association with cognitive rating scales. OH was significantly associated with PDD/PD-MCI (OR, 95% CI: 3.31, 2.16-5.08; k=18, n=2251; p<0.01). OH association with PDD (4.64, 2.68-8.02; k=13, n=1194; p<0.01) was stronger than with PD-MCI (1.82, 0.92-3.58; k=5, n=1056; p=NS). The association between OH and PD-MCI/PDD was stronger in studies with a higher proportion of women and in those with a lower frequency of supine hypertension. Global cognition rating scale scores were lower in patients with OH (SMD, 95% CI: -0.55, -0.83/-0.26; k= 12, n= 1427; p<0.01). Conclusions. Orthostatic hypotension shows as a significant risk factor for cognitive impairment in PD, especially in women and patients not suffering from hypertension.
format Artículo
author Loureiro, Débora
Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
author_facet Loureiro, Débora
Bilbao, Rodrigo
Bordet, Sofía
Grasso, Lina
Otero Losada, Matilde
Capani, Francisco
Ponzo, Osvaldo J.
Pérez Lloret, Santiago
author_sort Loureiro, Débora
title A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_short A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_full A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_fullStr A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_full_unstemmed A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson's disease
title_sort systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in parkinson's disease
publisher Springer
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16231
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