On the diagnosis of pain in Parkinson disease : a mechanism-based approach
Abstract: We read with interest the article entitled “Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease” from Timothy Lawn et al. Their review summarized the current findings on pain processing as well as on pharmacotherapy of pain in...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Lippinkott
2023
|
| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/16227 |
| Aporte de: |
| Sumario: | Abstract: We read with interest the article entitled “Pain in the neurodegenerating
brain: insights into pharmacotherapy for Alzheimer
disease and Parkinson disease” from Timothy Lawn et al. Their
review summarized the current findings on pain processing as
well as on pharmacotherapy of pain in both diseases. It further
emphasizes the importance of mechanistic research for
evidence-based pain medicine.
We would like to comment on the experimental findings and
on the importance of a mechanism-based approach in
Parkinson disease (PD) after the correct diagnosis of PDrelated
pain has been made because a mechanism-based
approach has been already validated. Concerning experimental
pain sensitivity, studies revealed increased pain
sensitivity when tested in the medication defined off
phase, whereas converse observations were made in
the on phase. Increased pain sensitivity can be reversed by
L-dopa or deep brain stimulation. |
|---|