Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy

Abstract: Background: Multiple System Atrophy (MSA) is a rare neurodegenerative disease with pronounced autonomic failure (AF). Severe cardiovascular AF is associated with poor prognosis. Since sweating dysfunction is less well known, we investigated the interest of a quick and non-invasive assess...

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Autores principales: Georges, Claire, Pérez Lloret, Santiago, Ory Magne, Fabienne, Fabbri, Margherita, Foubert Samier, Alexandra, Meissner, Wassilios G., Rascol, Olivier, Pavy-Le Traon, Anne
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
ATROFIA MULTISISTÉMICA
ENFERMEDADES NEURODEGENERATIVAS
DISFUNCION VENTRICULAR
SISTEMA NERVIOSO AUTONOMO
SUDORACIÓN
HIPERTENSION ARTERIAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15470
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15470
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spelling I33-R139-123456789-154702024-03-12T12:17:46Z Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy Georges, Claire Pérez Lloret, Santiago Ory Magne, Fabienne Fabbri, Margherita Foubert Samier, Alexandra Meissner, Wassilios G. Rascol, Olivier Pavy-Le Traon, Anne ATROFIA MULTISISTÉMICA ENFERMEDADES NEURODEGENERATIVAS DISFUNCION VENTRICULAR SISTEMA NERVIOSO AUTONOMO SUDORACIÓN HIPERTENSION ARTERIAL Abstract: Background: Multiple System Atrophy (MSA) is a rare neurodegenerative disease with pronounced autonomic failure (AF). Severe cardiovascular AF is associated with poor prognosis. Since sweating dysfunction is less well known, we investigated the interest of a quick and non-invasive assessment of sweating using electrochemical skin conductance (ESC) as a marker for AF in MSA. Methods: 138 MSA patients of the French Reference center for MSA with an annual follow-up including the Unified MSA Rating Scale (UMSARS), COMPASS (autonomic symptoms) and measurements of foot and hand ESC (Sudoscan®) participated to this study (age 65 ± 8 years, 66% probable MSA, 72% AMS-P). Statistical analysis included: (i) correlations between ESC and MSA type, age, disease duration, severity, blood pressure (BP), COMPASS, (ii) comparisons between groups with normal or abnormal ESC, and (iii) multivariate analysis by logistic regression. Relationships between severity progression during follow-up with ESC and other variables were modeled by Generalized Estimating Equation. Results: Hands and feet ESCs were abnormal in 81/138 (59%) and 93/138 (67%) cases, respectively. Abnormal ESCs were significantly correlated to disease severity and several features of AF. ESCs worsening over time was more pronounced than other autonomic features such as orthostatic hypotension. Abnormal ESCs at baseline were significantly associated with a higher progression of UMSARS’s score during follow-up. Conclusion: Sweating dysfunction assessed by ESC is frequent in MSA and is significantly related to disease severity and AF. The gradual decrease in ESC with disease duration could be useful as a quantitative marker of autonomic dysfunction. 2022-11-14T14:41:35Z 2022-11-14T14:41:35Z 2022 Artículo Georges, C. et al. Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy [en línea]. Parkinsonism & Related Disorders. 2022, 103. doi: 10.1016/j.parkreldis.2022.08.026. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15470 1353-8020 https://repositorio.uca.edu.ar/handle/123456789/15470 10.1016/j.parkreldis.2022.08.026 36063705 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Parkinsonism & Related Disorders. 2022, 103
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ATROFIA MULTISISTÉMICA
ENFERMEDADES NEURODEGENERATIVAS
DISFUNCION VENTRICULAR
SISTEMA NERVIOSO AUTONOMO
SUDORACIÓN
HIPERTENSION ARTERIAL
spellingShingle ATROFIA MULTISISTÉMICA
ENFERMEDADES NEURODEGENERATIVAS
DISFUNCION VENTRICULAR
SISTEMA NERVIOSO AUTONOMO
SUDORACIÓN
HIPERTENSION ARTERIAL
Georges, Claire
Pérez Lloret, Santiago
Ory Magne, Fabienne
Fabbri, Margherita
Foubert Samier, Alexandra
Meissner, Wassilios G.
Rascol, Olivier
Pavy-Le Traon, Anne
Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
topic_facet ATROFIA MULTISISTÉMICA
ENFERMEDADES NEURODEGENERATIVAS
DISFUNCION VENTRICULAR
SISTEMA NERVIOSO AUTONOMO
SUDORACIÓN
HIPERTENSION ARTERIAL
description Abstract: Background: Multiple System Atrophy (MSA) is a rare neurodegenerative disease with pronounced autonomic failure (AF). Severe cardiovascular AF is associated with poor prognosis. Since sweating dysfunction is less well known, we investigated the interest of a quick and non-invasive assessment of sweating using electrochemical skin conductance (ESC) as a marker for AF in MSA. Methods: 138 MSA patients of the French Reference center for MSA with an annual follow-up including the Unified MSA Rating Scale (UMSARS), COMPASS (autonomic symptoms) and measurements of foot and hand ESC (Sudoscan®) participated to this study (age 65 ± 8 years, 66% probable MSA, 72% AMS-P). Statistical analysis included: (i) correlations between ESC and MSA type, age, disease duration, severity, blood pressure (BP), COMPASS, (ii) comparisons between groups with normal or abnormal ESC, and (iii) multivariate analysis by logistic regression. Relationships between severity progression during follow-up with ESC and other variables were modeled by Generalized Estimating Equation. Results: Hands and feet ESCs were abnormal in 81/138 (59%) and 93/138 (67%) cases, respectively. Abnormal ESCs were significantly correlated to disease severity and several features of AF. ESCs worsening over time was more pronounced than other autonomic features such as orthostatic hypotension. Abnormal ESCs at baseline were significantly associated with a higher progression of UMSARS’s score during follow-up. Conclusion: Sweating dysfunction assessed by ESC is frequent in MSA and is significantly related to disease severity and AF. The gradual decrease in ESC with disease duration could be useful as a quantitative marker of autonomic dysfunction.
format Artículo
author Georges, Claire
Pérez Lloret, Santiago
Ory Magne, Fabienne
Fabbri, Margherita
Foubert Samier, Alexandra
Meissner, Wassilios G.
Rascol, Olivier
Pavy-Le Traon, Anne
author_facet Georges, Claire
Pérez Lloret, Santiago
Ory Magne, Fabienne
Fabbri, Margherita
Foubert Samier, Alexandra
Meissner, Wassilios G.
Rascol, Olivier
Pavy-Le Traon, Anne
author_sort Georges, Claire
title Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
title_short Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
title_full Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
title_fullStr Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
title_full_unstemmed Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
title_sort alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15470
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AT perezlloretsantiago alterationsinelectrochemicalskinconductanceasamarkerofautonomicdysfunctioninmultiplesystematrophy
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AT fabbrimargherita alterationsinelectrochemicalskinconductanceasamarkerofautonomicdysfunctioninmultiplesystematrophy
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AT rascololivier alterationsinelectrochemicalskinconductanceasamarkerofautonomicdysfunctioninmultiplesystematrophy
AT pavyletraonanne alterationsinelectrochemicalskinconductanceasamarkerofautonomicdysfunctioninmultiplesystematrophy
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