Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen

Abstract: Aims: The accumulated evidence suggests that lifestyle - specifically dietary habits and stress exposure - plays a detrimental role in health. The purpose of the present study was to analyze the interplay of stress, diet, and sex in metabolic and cognitive alterations. Main methods: For...

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Autores principales: Prochnika, Andrés, Burgueño, Adriana Laura, Rubinstein Guichón, Mara Roxana, Marcone, María Paula, Bianchi, María S., González Murano, María Rosa, Genaro, Ana María, Wald, Miriam Ruth
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
HABITOS ALIMENTARIOS
DIETA RICA EN GRASAS
STRESS
SEXO
COGNICION
METABOLISMO
NEUROTROFINAS
LINFOCITOS PERIFÉRICOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15451
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15451
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic HABITOS ALIMENTARIOS
DIETA RICA EN GRASAS
STRESS
SEXO
COGNICION
METABOLISMO
NEUROTROFINAS
LINFOCITOS PERIFÉRICOS
spellingShingle HABITOS ALIMENTARIOS
DIETA RICA EN GRASAS
STRESS
SEXO
COGNICION
METABOLISMO
NEUROTROFINAS
LINFOCITOS PERIFÉRICOS
Prochnika, Andrés
Burgueño, Adriana Laura
Rubinstein Guichón, Mara Roxana
Marcone, María Paula
Bianchi, María S.
González Murano, María Rosa
Genaro, Ana María
Wald, Miriam Ruth
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
topic_facet HABITOS ALIMENTARIOS
DIETA RICA EN GRASAS
STRESS
SEXO
COGNICION
METABOLISMO
NEUROTROFINAS
LINFOCITOS PERIFÉRICOS
description Abstract: Aims: The accumulated evidence suggests that lifestyle - specifically dietary habits and stress exposure - plays a detrimental role in health. The purpose of the present study was to analyze the interplay of stress, diet, and sex in metabolic and cognitive alterations. Main methods: For this purpose, one-month-old C57Bl/6J mice were fed with a standard diet or high-fat diet (HFD). After eight weeks, one subgroup of mice from each respective diet was exposed to 20 weeks of chronic mild stress (CMS), whilst the others were left undisturbed. Key findings: After 28 weeks of HFD feeding, mice from both sexes were overweight, with an increase in caloric intake and abdominal and subcutaneous fat pads. Stress exposure induced a decrease in body weight, related to a decrease in caloric efficiency in both males and females. Results indicate that males are more susceptible than the females in modulating metabolic and cognitive functions under HFD and CMS. Although both sexes demonstrated HFD-induced weight gain, fat accumulation, insulin resistance, high cholesterol, only males exposed to CMS but not females have (i) impaired glucose tolerance with higher glucose level; (ii) significant prolonged latency in Barnes test, suggesting cognitive impairment; (iii) increased IFN-gamma expression in hippocampus, suggesting greater neuroinflammatory response; (iv) poorer cognitive performance related to a decrease in hippocampal and spleen BDNF mRNA expression. Significance: The main finding in this study is the presence of a sexual dimorphism in modulating metabolic and cognitive functions under HFD and CMS, showing males are more susceptible than females. In addition, poorer cognitive performance was related to a decrease in hippocampal BDNF mRNA expression. Interestingly, these changes were observed in the spleen as well.
format Artículo
author Prochnika, Andrés
Burgueño, Adriana Laura
Rubinstein Guichón, Mara Roxana
Marcone, María Paula
Bianchi, María S.
González Murano, María Rosa
Genaro, Ana María
Wald, Miriam Ruth
author_facet Prochnika, Andrés
Burgueño, Adriana Laura
Rubinstein Guichón, Mara Roxana
Marcone, María Paula
Bianchi, María S.
González Murano, María Rosa
Genaro, Ana María
Wald, Miriam Ruth
author_sort Prochnika, Andrés
title Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
title_short Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
title_full Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
title_fullStr Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
title_full_unstemmed Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
title_sort sexual dimorphism modulates metabolic and cognitive alterations under hfd nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and bdnf mrna expression in hippocampus and spleen
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15451
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