Melatonin : a promising drug to ameliorate main human space exploration risks

Abstract: Melatonin is a small indole molecule synthesized by most cells in the mammalian body. Circulating melatonin secreted by the pineal gland is a circadian signal that regulates main rhythmic physiological processes, including sleep-wake cycle and biological rhythms in cardiovascular function,...

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Detalles Bibliográficos
Autores principales: Vigo, Daniel Eduardo, Plano, Santiago Andrés, Demaría Pesce, Víctor, Cardinali, Daniel Pedro
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Springer 2022
Materias:
MELATONINA
FISIOLOGIA
GLANDULA PINEAL
RITMO CIRCADIANO
ESPACIO
RADIACION
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15401
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15401
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
FISIOLOGIA
GLANDULA PINEAL
RITMO CIRCADIANO
ESPACIO
RADIACION
spellingShingle MELATONINA
FISIOLOGIA
GLANDULA PINEAL
RITMO CIRCADIANO
ESPACIO
RADIACION
Vigo, Daniel Eduardo
Plano, Santiago Andrés
Demaría Pesce, Víctor
Cardinali, Daniel Pedro
Melatonin : a promising drug to ameliorate main human space exploration risks
topic_facet MELATONINA
FISIOLOGIA
GLANDULA PINEAL
RITMO CIRCADIANO
ESPACIO
RADIACION
description Abstract: Melatonin is a small indole molecule synthesized by most cells in the mammalian body. Circulating melatonin secreted by the pineal gland is a circadian signal that regulates main rhythmic physiological processes, including sleep-wake cycle and biological rhythms in cardiovascular function, metabolism, and immune response. Both intracellular and extracellular melatonin have been shown to act as an effective protector for free radicals molecular and tissue injury. During human space exploration crewmembers will be exposed to several risks, including exposure to radiation in the form of high-energy galactic cosmic rays and solar particle events, bone loss and neurological disorders induced by microgravity, and sleep disruption. Due to its important chronobiotic and cytoprotective effect, melatonin treatment could be a potential effective strategy to protect against most space radiation hazards. It has an anti-osteoclastogenic activity and a pro-osteoblastic activity that may reduce bone-loss induced by microgravity. Also, melatonin is potentially effective to prevent neurodegeneration that may result from long term space exploration. Finally, its chronobiotic and hypnotic properties may help to improve sleep and circadian synchronization, decreasing in turn, the risk of fatigue, performance decrements and adverse health outcomes. Melatonin was presumably present from the very beginning of life in Earth and evidence suggests that it could be a helpful partner for our first steps outside the planet.
format Parte de libro
author Vigo, Daniel Eduardo
Plano, Santiago Andrés
Demaría Pesce, Víctor
Cardinali, Daniel Pedro
author_facet Vigo, Daniel Eduardo
Plano, Santiago Andrés
Demaría Pesce, Víctor
Cardinali, Daniel Pedro
author_sort Vigo, Daniel Eduardo
title Melatonin : a promising drug to ameliorate main human space exploration risks
title_short Melatonin : a promising drug to ameliorate main human space exploration risks
title_full Melatonin : a promising drug to ameliorate main human space exploration risks
title_fullStr Melatonin : a promising drug to ameliorate main human space exploration risks
title_full_unstemmed Melatonin : a promising drug to ameliorate main human space exploration risks
title_sort melatonin : a promising drug to ameliorate main human space exploration risks
publisher Springer
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15401
work_keys_str_mv AT vigodanieleduardo melatoninapromisingdrugtoamelioratemainhumanspaceexplorationrisks
AT planosantiagoandres melatoninapromisingdrugtoamelioratemainhumanspaceexplorationrisks
AT demariapescevictor melatoninapromisingdrugtoamelioratemainhumanspaceexplorationrisks
AT cardinalidanielpedro melatoninapromisingdrugtoamelioratemainhumanspaceexplorationrisks
bdutipo_str Repositorios
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