Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder

Abstract: Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which modulates heart rate variability (HRV), comprises brain regions that...

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Autores principales: Wainsztein, Agustina E., Castro, Mariana N., Goldberg, Ximena, Camacho-Téllez, Vicente, Vulcano, Mercedes, Abulafia, Carolina Andrea, Ladrón de Guevara, María Soledad, Cardoner, Narcís, Nemeroff, Charles B., Menchón, José M., Soriano-Mas, Carles, Villarreal, Mirta F., Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
REGULACION EMOCIONAL
DEPRESION
RESONANCIA MAGNETICA NUCLEAR
BORDERLINE
SISTEMA NERVIOSO AUTONOMO
ADVERSIDAD VIDA TEMPRANA
TRASTORNO PSICOLOGICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15356
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Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15356
record_format dspace
spelling I33-R139-123456789-153562024-03-26T11:32:23Z Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder Wainsztein, Agustina E. Castro, Mariana N. Goldberg, Ximena Camacho-Téllez, Vicente Vulcano, Mercedes Abulafia, Carolina Andrea Ladrón de Guevara, María Soledad Cardoner, Narcís Nemeroff, Charles B. Menchón, José M. Soriano-Mas, Carles Villarreal, Mirta F. Guinjoan, Salvador M. REGULACION EMOCIONAL DEPRESION RESONANCIA MAGNETICA NUCLEAR BORDERLINE SISTEMA NERVIOSO AUTONOMO ADVERSIDAD VIDA TEMPRANA TRASTORNO PSICOLOGICO Abstract: Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which modulates heart rate variability (HRV), comprises brain regions that mediate emotion regulation processes. However, it remains unclear the effect of ACEs on CAN dynamics and its relationship with HRV in these disorders. We studied the effects of ACEs on the brain and HRV simultaneously, during regulation of psychological stress in 19 BPD, 20 MDD and 20 healthy controls (HC). Participants underwent a cognitive reappraisal task during fMRI with simultaneous ECG acquisition. ACEs exposure was associated with increased activity of CAN and salience network components in patients with MDD compared to BPD during cognitive reappraisal. A brain-autonomic coupling was found in BPD relative to HC during emotion regulation, whereby greater activity of left anterior cingulate and medial superior frontal gyrus areas was coupled with increased HRV. Results suggest that ACEs exposure is associated with a distinct activation of the CAN and salience network regions governing responses to psychological stress in MDD compared to BPD. These alterations may constitute a distinctive neurobiological mechanism for abnormal emotion processing and regulation related to ACEs in MDD. 2022-10-28T13:20:21Z 2022-10-28T13:20:21Z 2021 Artículo Wainsztein, A. E. et al. Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder [en línea]. Psychiatry Research Neuroimaging. 2021, 318, 111394. doi: 10.1016/j.pscychresns.2021.111394. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15356 0925-4927 https://repositorio.uca.edu.ar/handle/123456789/15356 10.1016/j.pscychresns.2021.111394 34673383 eng Acceso restringido http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Psychiatry Research Neuroimaging. 2021, 318, 111394
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic REGULACION EMOCIONAL
DEPRESION
RESONANCIA MAGNETICA NUCLEAR
BORDERLINE
SISTEMA NERVIOSO AUTONOMO
ADVERSIDAD VIDA TEMPRANA
TRASTORNO PSICOLOGICO
spellingShingle REGULACION EMOCIONAL
DEPRESION
RESONANCIA MAGNETICA NUCLEAR
BORDERLINE
SISTEMA NERVIOSO AUTONOMO
ADVERSIDAD VIDA TEMPRANA
TRASTORNO PSICOLOGICO
Wainsztein, Agustina E.
Castro, Mariana N.
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Abulafia, Carolina Andrea
Ladrón de Guevara, María Soledad
Cardoner, Narcís
Nemeroff, Charles B.
Menchón, José M.
Soriano-Mas, Carles
Villarreal, Mirta F.
Guinjoan, Salvador M.
Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
topic_facet REGULACION EMOCIONAL
DEPRESION
RESONANCIA MAGNETICA NUCLEAR
BORDERLINE
SISTEMA NERVIOSO AUTONOMO
ADVERSIDAD VIDA TEMPRANA
TRASTORNO PSICOLOGICO
description Abstract: Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which modulates heart rate variability (HRV), comprises brain regions that mediate emotion regulation processes. However, it remains unclear the effect of ACEs on CAN dynamics and its relationship with HRV in these disorders. We studied the effects of ACEs on the brain and HRV simultaneously, during regulation of psychological stress in 19 BPD, 20 MDD and 20 healthy controls (HC). Participants underwent a cognitive reappraisal task during fMRI with simultaneous ECG acquisition. ACEs exposure was associated with increased activity of CAN and salience network components in patients with MDD compared to BPD during cognitive reappraisal. A brain-autonomic coupling was found in BPD relative to HC during emotion regulation, whereby greater activity of left anterior cingulate and medial superior frontal gyrus areas was coupled with increased HRV. Results suggest that ACEs exposure is associated with a distinct activation of the CAN and salience network regions governing responses to psychological stress in MDD compared to BPD. These alterations may constitute a distinctive neurobiological mechanism for abnormal emotion processing and regulation related to ACEs in MDD.
format Artículo
author Wainsztein, Agustina E.
Castro, Mariana N.
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Abulafia, Carolina Andrea
Ladrón de Guevara, María Soledad
Cardoner, Narcís
Nemeroff, Charles B.
Menchón, José M.
Soriano-Mas, Carles
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_facet Wainsztein, Agustina E.
Castro, Mariana N.
Goldberg, Ximena
Camacho-Téllez, Vicente
Vulcano, Mercedes
Abulafia, Carolina Andrea
Ladrón de Guevara, María Soledad
Cardoner, Narcís
Nemeroff, Charles B.
Menchón, José M.
Soriano-Mas, Carles
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_sort Wainsztein, Agustina E.
title Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
title_short Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
title_full Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
title_fullStr Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
title_full_unstemmed Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
title_sort childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15356
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