Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin

Abstract: The recent advances in psycho-neuroendocrino-immunology (PNEI) have demonstrated the existence of a natural anticancer neuroendocrine system, mainly expressed by the pineal gland, endocannabinoid system, oxytocin, and Ang 1-7. Moreover, cancer progression has appeared to be associated wi...

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Detalles Bibliográficos
Autores principales: Lissoni, Paolo, Colgiago, Massimo, Rovelli, Franco, Messina, Giusy, Porro, Giorgio, Monzon, Alejandra, Merlini, Desirée, Di Fede, Giuseppe, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Crimson Publishers 2022
Materias:
MELATONINA
CANNABINOIDES
NEUROINMUNOMODULACION
OXITOCINA
CANCER
CANCER DE MAMA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15212
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15212
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
CANNABINOIDES
NEUROINMUNOMODULACION
OXITOCINA
CANCER
CANCER DE MAMA
spellingShingle MELATONINA
CANNABINOIDES
NEUROINMUNOMODULACION
OXITOCINA
CANCER
CANCER DE MAMA
Lissoni, Paolo
Colgiago, Massimo
Rovelli, Franco
Messina, Giusy
Porro, Giorgio
Monzon, Alejandra
Merlini, Desirée
Di Fede, Giuseppe
Cardinali, Daniel Pedro
Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
topic_facet MELATONINA
CANNABINOIDES
NEUROINMUNOMODULACION
OXITOCINA
CANCER
CANCER DE MAMA
description Abstract: The recent advances in psycho-neuroendocrino-immunology (PNEI) have demonstrated the existence of a natural anticancer neuroendocrine system, mainly expressed by the pineal gland, endocannabinoid system, oxytocin, and Ang 1-7. Moreover, cancer progression has appeared to be associated with a progressive decline in the pineal and cannabinoid system functions. A new approach to cancer therapy according to a PNEI strategy could simply consist of the correction of the main cancer-related neuroimmune and neuroendocrine alterations through the exogenous administration of the same human natural anticancer molecules, whose production declines with cancer progression. PNEI therapy of cancer, because of its complete lack of toxicity, could be applied also to patients, who failed to respond to the conventional anticancer treatments. Most data available up to now regard the treatment with the pineal anticancer hormone melatonin (MLT), whose efficacy has been proven to be a dose-dependent phenomenon. Preliminary results with other human antitumor molecules, mainly the pineal indole 5-MTT, cannabinoids, oxytocin and probably in particular Ang 1-7, could further amplify the already interesting results obtained with high-dose MLT alone in untreatable advanced cancer patients.
format Artículo
author Lissoni, Paolo
Colgiago, Massimo
Rovelli, Franco
Messina, Giusy
Porro, Giorgio
Monzon, Alejandra
Merlini, Desirée
Di Fede, Giuseppe
Cardinali, Daniel Pedro
author_facet Lissoni, Paolo
Colgiago, Massimo
Rovelli, Franco
Messina, Giusy
Porro, Giorgio
Monzon, Alejandra
Merlini, Desirée
Di Fede, Giuseppe
Cardinali, Daniel Pedro
author_sort Lissoni, Paolo
title Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
title_short Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
title_full Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
title_fullStr Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
title_full_unstemmed Psycho Neuroendocrino Immune (PNEI) therapy of cancer beyond melatonin
title_sort psycho neuroendocrino immune (pnei) therapy of cancer beyond melatonin
publisher Crimson Publishers
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15212
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