Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1

Abstract: Chronic disruption of circadian rhythms which include intricate molecular transcription-translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology. Sirtuins (SIRTs) are nuclear, cytoplasmic and mitocho...

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Autores principales: Soni, Sanjeev Kumar, Basu, Priyoneel, Singaravel, Muniyandi, Sharma, Ramaswamy, Pandi Perumal, Seithikurippu R., Cardinali, Daniel Pedro, Reiter, Russel J.
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer Nature 2022
Materias:
CALCIO
RITMO CIRCADIANO
CORAZON
MELATONINA
SIRTUINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15202
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15202
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CALCIO
RITMO CIRCADIANO
CORAZON
MELATONINA
SIRTUINA
spellingShingle CALCIO
RITMO CIRCADIANO
CORAZON
MELATONINA
SIRTUINA
Soni, Sanjeev Kumar
Basu, Priyoneel
Singaravel, Muniyandi
Sharma, Ramaswamy
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, Russel J.
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
topic_facet CALCIO
RITMO CIRCADIANO
CORAZON
MELATONINA
SIRTUINA
description Abstract: Chronic disruption of circadian rhythms which include intricate molecular transcription-translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology. Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clock with clock-controlled oscillatory protein, NAMPT, and its metabolite NAD+. Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway. This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK. SIRT1 is involved in the development of cardiomyocytes, regulation of voltage-gated cardiac sodium ion channels via deacetylation, prevention of atherosclerotic plaque formation in the cardiovascular system, protection against oxidative damage and anti-thrombotic actions. Overall, SIRT1 has a see-saw effect on cardioprotection, with low levels being cardioprotective and higher levels leading to cardiac hypertrophy.
format Artículo
author Soni, Sanjeev Kumar
Basu, Priyoneel
Singaravel, Muniyandi
Sharma, Ramaswamy
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, Russel J.
author_facet Soni, Sanjeev Kumar
Basu, Priyoneel
Singaravel, Muniyandi
Sharma, Ramaswamy
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, Russel J.
author_sort Soni, Sanjeev Kumar
title Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
title_short Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
title_full Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
title_fullStr Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
title_full_unstemmed Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
title_sort sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
publisher Springer Nature
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15202
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bdutipo_str Repositorios
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