Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis

Abstract: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be rel...

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Autores principales: Kölliker Frers, Rodolfo, Otero Losada, Matilde, Kobiec, Tamara, Udovin, Lucas Daniel, Aon Bertolino, María Laura, Herrera, María Inés, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: 2022
Materias:
ESCLEROSIS MULTIPLE
DIAGNOSTICO
NEUROFILAMENTOS
DAÑO CEREBRAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15188
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15188
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESCLEROSIS MULTIPLE
DIAGNOSTICO
NEUROFILAMENTOS
DAÑO CEREBRAL
spellingShingle ESCLEROSIS MULTIPLE
DIAGNOSTICO
NEUROFILAMENTOS
DAÑO CEREBRAL
Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Udovin, Lucas Daniel
Aon Bertolino, María Laura
Herrera, María Inés
Capani, Francisco
Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
topic_facet ESCLEROSIS MULTIPLE
DIAGNOSTICO
NEUROFILAMENTOS
DAÑO CEREBRAL
description Abstract: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations. Axonal damage associated with the inflammatory process causes neurofilaments, the major neuron structural proteins, to be released into the extracellular space, reaching the cerebrospinal fluid (CSF) and the peripheral blood. Methodological advances in neurofilaments’ serological detection and imaging technology, along with many clinical and therapeutic studies in the last years, have deepened our understanding of MS immunopathogenesis. This review examines the use of light chain neurofilaments (NFLs) as peripheral MS biomarkers in light of the current clinical and therapeutic evidence, MS immunopathology, and technological advances in diagnostic tools. It aims to highlight NFL multidimensional value as a reliable MS biomarker with a diagnostic-prognostic profile while improving our comprehension of inflammatory neurodegenerative processes, mainly RRMS, the most frequent clinical presentation of MS.
format Artículo
author Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Udovin, Lucas Daniel
Aon Bertolino, María Laura
Herrera, María Inés
Capani, Francisco
author_facet Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Udovin, Lucas Daniel
Aon Bertolino, María Laura
Herrera, María Inés
Capani, Francisco
author_sort Kölliker Frers, Rodolfo
title Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
title_short Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
title_full Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
title_fullStr Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
title_full_unstemmed Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
title_sort multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15188
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