Histamine in cancer immunology and immunotherapy : current status and new perspectives

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Abstract: Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting...

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Autores principales: Sarasola, María de la Paz, Táquez Delgado, Mónica Alejandra, Nicoud, Melisa Beatriz, Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: British Pharmacological Society 2022
Materias:
CANCER DE MAMA
INMUNIDAD ADAPTATIVA
INMUNIDAD ANTITUMORAL
RECEPTORES DE HISTAMINA
INMUNOTERAPIA
INMUNIDAD INNATA
LEUCEMIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15128
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15128
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER DE MAMA
INMUNIDAD ADAPTATIVA
INMUNIDAD ANTITUMORAL
RECEPTORES DE HISTAMINA
INMUNOTERAPIA
INMUNIDAD INNATA
LEUCEMIA
spellingShingle CANCER DE MAMA
INMUNIDAD ADAPTATIVA
INMUNIDAD ANTITUMORAL
RECEPTORES DE HISTAMINA
INMUNOTERAPIA
INMUNIDAD INNATA
LEUCEMIA
Sarasola, María de la Paz
Táquez Delgado, Mónica Alejandra
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
Histamine in cancer immunology and immunotherapy : current status and new perspectives
topic_facet CANCER DE MAMA
INMUNIDAD ADAPTATIVA
INMUNIDAD ANTITUMORAL
RECEPTORES DE HISTAMINA
INMUNOTERAPIA
INMUNIDAD INNATA
LEUCEMIA
description Abstract: Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine-tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine-producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.
format Artículo
author Sarasola, María de la Paz
Táquez Delgado, Mónica Alejandra
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
author_facet Sarasola, María de la Paz
Táquez Delgado, Mónica Alejandra
Nicoud, Melisa Beatriz
Medina, Vanina Araceli
author_sort Sarasola, María de la Paz
title Histamine in cancer immunology and immunotherapy : current status and new perspectives
title_short Histamine in cancer immunology and immunotherapy : current status and new perspectives
title_full Histamine in cancer immunology and immunotherapy : current status and new perspectives
title_fullStr Histamine in cancer immunology and immunotherapy : current status and new perspectives
title_full_unstemmed Histamine in cancer immunology and immunotherapy : current status and new perspectives
title_sort histamine in cancer immunology and immunotherapy : current status and new perspectives
publisher British Pharmacological Society
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15128
work_keys_str_mv AT sarasolamariadelapaz histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives
AT taquezdelgadomonicaalejandra histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives
AT nicoudmelisabeatriz histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives
AT medinavaninaaraceli histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives
bdutipo_str Repositorios
_version_ 1764820525527334912

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