Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics

Abstarct Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing...

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Autores principales: Naranjo, María Eugenia G., Rodrigues Soares, Fernanda, Peñas Lledó, Eva M., Tarazona Santos, Eduardo, Fariñas, Humberto, Rodeiro, Idania, Terán, Enrique, Grazina, Manuela, Moya, Graciela E., López López, Marisol, Sarmiento, Alba P., Calzadilla, Luis R., Ramírez Roa, Ronald, Ortiz López, Rocío, Estévez Carrizo, Francisco E., Sosa Macías, Martha, Barrantes, Ramiro, LLerena, Adrián
Formato: Artículo
Lenguaje:Inglés
Publicado: Mary Ann Liebert 2022
Materias:
FARMACOGENETICA
GENOTIPOS
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/15119
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-15119
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic FARMACOGENETICA
GENOTIPOS
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
spellingShingle FARMACOGENETICA
GENOTIPOS
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
Naranjo, María Eugenia G.
Rodrigues Soares, Fernanda
Peñas Lledó, Eva M.
Tarazona Santos, Eduardo
Fariñas, Humberto
Rodeiro, Idania
Terán, Enrique
Grazina, Manuela
Moya, Graciela E.
López López, Marisol
Sarmiento, Alba P.
Calzadilla, Luis R.
Ramírez Roa, Ronald
Ortiz López, Rocío
Estévez Carrizo, Francisco E.
Sosa Macías, Martha
Barrantes, Ramiro
LLerena, Adrián
Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
topic_facet FARMACOGENETICA
GENOTIPOS
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
description Abstarct Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing enzyme genotypes, which were subsequently utilized to catalog their "predicted drug metabolism phenotypes" across Native American and Ibero American populations. Importantly, we report in this study, a total of 6060 healthy individuals from Ibero-America who were classified according to their self-reported ancestry: 1395 Native Americans, 2571 Admixed Latin Americans, 96 Afro-Latin Americans, 287 white Latin Americans (from Cuba), 1537 Iberians, and 174 Argentinean Ashkenazi Jews. Moreover, Native Americans were grouped into North-, Central-, and South Amerindians (from Mexico, Costa Rica, and Peru, respectively). All subjects were studied for the most common and functional CYP2D6, CYP2C9, and CYP2C19 allelic variants, and grouped as genotype-predicted poor or ultrarapid metabolizer phenotypes (gPMs and gUMs, respectively). Native Americans showed differences from each ethnic group in at least two alleles of CYP2D6, CYP2C9, and CYP2C19. Native Americans had higher frequencies of wild-type alleles for all genes, and lower frequency of CYP2D6*41, CYP2C9*2, and CYP2C19*17 (p < 0.05). Native Americans also showed less CYP2C19 gUMs than the rest of the population sample. In addition, differences within Native Americans (mostly North vs. South) were also found. The interethnic differences described supports the need for population-specific personalized and precision medicine programs for Native Americans. To the best of our knowledge, this is the largest study carried out in Native Americans and other Ibero-American populations analyzing CYP2D6, CYP2C9, and CYP2C19 genetic polymorphisms. Population pharmacogenomics is a nascent field of global health and warrants further research and education.
format Artículo
author Naranjo, María Eugenia G.
Rodrigues Soares, Fernanda
Peñas Lledó, Eva M.
Tarazona Santos, Eduardo
Fariñas, Humberto
Rodeiro, Idania
Terán, Enrique
Grazina, Manuela
Moya, Graciela E.
López López, Marisol
Sarmiento, Alba P.
Calzadilla, Luis R.
Ramírez Roa, Ronald
Ortiz López, Rocío
Estévez Carrizo, Francisco E.
Sosa Macías, Martha
Barrantes, Ramiro
LLerena, Adrián
author_facet Naranjo, María Eugenia G.
Rodrigues Soares, Fernanda
Peñas Lledó, Eva M.
Tarazona Santos, Eduardo
Fariñas, Humberto
Rodeiro, Idania
Terán, Enrique
Grazina, Manuela
Moya, Graciela E.
López López, Marisol
Sarmiento, Alba P.
Calzadilla, Luis R.
Ramírez Roa, Ronald
Ortiz López, Rocío
Estévez Carrizo, Francisco E.
Sosa Macías, Martha
Barrantes, Ramiro
LLerena, Adrián
author_sort Naranjo, María Eugenia G.
title Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
title_short Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
title_full Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
title_fullStr Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
title_full_unstemmed Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics
title_sort interethnic variability in cyp2d6, cyp2c9, and cyp2c19 genes and predicted drug metabolism phenotypes among 6060 ibero- and native americans: ribef-ceiba consortium report on population pharmacogenomics
publisher Mary Ann Liebert
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/15119
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