Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder

Abstract: Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core sym...

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Autores principales: Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2022
Materias:
AUTISMO
TRASTORNO DEL ESPECTRO AUTISTA
NEUROCIENCIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14729
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14729
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic AUTISMO
TRASTORNO DEL ESPECTRO AUTISTA
NEUROCIENCIA
spellingShingle AUTISMO
TRASTORNO DEL ESPECTRO AUTISTA
NEUROCIENCIA
Vallés, Ana Sofía
Barrantes, Francisco José
Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
topic_facet AUTISMO
TRASTORNO DEL ESPECTRO AUTISTA
NEUROCIENCIA
description Abstract: Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD.
format Artículo
author Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Vallés, Ana Sofía
title Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
title_short Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
title_full Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
title_fullStr Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
title_full_unstemmed Dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
title_sort dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
publisher Frontiers Media
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14729
work_keys_str_mv AT vallesanasofia dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder
AT barrantesfranciscojose dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder
bdutipo_str Repositorios
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