Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress

Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated...

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Autores principales: Pascuan, C.G., Di Rosso, M.E., Pivoz-Avedikian, J.E., Wald, Miriam Ruth, Zorrilla Zubilete, M.A., Genaro, Ana María
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14598
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14598
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
spellingShingle ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
Pascuan, C.G.
Di Rosso, M.E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
topic_facet ESTRES PRENATAL
MEMORIA ESPACIAL
NEUROTROFINAS
CORTICOSTERONA
TRASTORNOS DE LA MEMORIA
EMBARAZO
description Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.
format Artículo
author Pascuan, C.G.
Di Rosso, M.E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
author_facet Pascuan, C.G.
Di Rosso, M.E.
Pivoz-Avedikian, J.E.
Wald, Miriam Ruth
Zorrilla Zubilete, M.A.
Genaro, Ana María
author_sort Pascuan, C.G.
title Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_short Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_full Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_fullStr Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_full_unstemmed Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
title_sort alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14598
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