Pharmacological targeting of histamine H4 receptor in periodontal disease

Abstract: Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. Methods: B...

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Autores principales: Prestifilippo, J. P., Fernandez Solari, J., Martinel Lamas, D.J., Rios, C.E., Mohn, C., Perazzo, J.C., Rivera, E.S., Elverdin, J.C., Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: John Wiley & Sons 2022
Materias:
ANTAGONISTAS DE LOS RECEPTORES HISTAMINICOS
PERIODONTITIS
GLÁNDULA SUBMANDIBULAR
APOPTOSIS
INFLAMACIÓN
GINGIVITIS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14561
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14561
record_format dspace
spelling I33-R139-123456789-145612023-11-23T16:58:56Z Pharmacological targeting of histamine H4 receptor in periodontal disease Prestifilippo, J. P. Fernandez Solari, J. Martinel Lamas, D.J. Rios, C.E. Mohn, C. Perazzo, J.C. Rivera, E.S. Elverdin, J.C. Medina, Vanina Araceli ANTAGONISTAS DE LOS RECEPTORES HISTAMINICOS PERIODONTITIS GLÁNDULA SUBMANDIBULAR APOPTOSIS INFLAMACIÓN GINGIVITIS Abstract: Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. Methods: Bilateral EP was induced for 2 weeks in anaesthetized male rats. The effect of systemic and local administration of H4R antagonists (JNJ7777120, JNJ10191584) on histopathology and functionality of SMG, bone loss and gingival inflammation was evaluated. Results: The subcutaneous administration of JNJ7777120 prevented periodontitis-induced SMG histological injury, reducing vacuolization and apoptosis and additionally reversed the increased prostaglandin E2 (PGE2) levels in SMG while it partially reversed the methacholine-induced salivation reduction produced by periodontitis. JNJ7777120 attenuated bone loss and the increased PGE2 levels and inflammatory infiltration in gingival tissue of rats with periodontitis. Finally, local administration of JNJ7777120 and JNJ10191584 was also beneficial for improving periodontal parameters. Conclusions: H4 receptor antagonists are able to ameliorate periodontitis-induced injury on SMG, gingival tissue and bone structure, suggesting that pharmacological targeting of H4R could be an attractive strategy to improve periodontal health. 2022-07-26T12:49:07Z 2022-07-26T12:49:07Z 2016 Artículo Prestifilippo, J. P. et al. Pharmacological targeting of histamine H4 receptor in periodontal disease [en línea]. Oral Diseases. 2016, 22 (5). doi: 10.1111/odi.12467. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14561 1601-0825 (online) 1354-523X https://repositorio.uca.edu.ar/handle/123456789/14561 10.1111/odi.12467 26919586 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf John Wiley & Sons Oral Diseases Vol.22, No. 5, 2016
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ANTAGONISTAS DE LOS RECEPTORES HISTAMINICOS
PERIODONTITIS
GLÁNDULA SUBMANDIBULAR
APOPTOSIS
INFLAMACIÓN
GINGIVITIS
spellingShingle ANTAGONISTAS DE LOS RECEPTORES HISTAMINICOS
PERIODONTITIS
GLÁNDULA SUBMANDIBULAR
APOPTOSIS
INFLAMACIÓN
GINGIVITIS
Prestifilippo, J. P.
Fernandez Solari, J.
Martinel Lamas, D.J.
Rios, C.E.
Mohn, C.
Perazzo, J.C.
Rivera, E.S.
Elverdin, J.C.
Medina, Vanina Araceli
Pharmacological targeting of histamine H4 receptor in periodontal disease
topic_facet ANTAGONISTAS DE LOS RECEPTORES HISTAMINICOS
PERIODONTITIS
GLÁNDULA SUBMANDIBULAR
APOPTOSIS
INFLAMACIÓN
GINGIVITIS
description Abstract: Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. Methods: Bilateral EP was induced for 2 weeks in anaesthetized male rats. The effect of systemic and local administration of H4R antagonists (JNJ7777120, JNJ10191584) on histopathology and functionality of SMG, bone loss and gingival inflammation was evaluated. Results: The subcutaneous administration of JNJ7777120 prevented periodontitis-induced SMG histological injury, reducing vacuolization and apoptosis and additionally reversed the increased prostaglandin E2 (PGE2) levels in SMG while it partially reversed the methacholine-induced salivation reduction produced by periodontitis. JNJ7777120 attenuated bone loss and the increased PGE2 levels and inflammatory infiltration in gingival tissue of rats with periodontitis. Finally, local administration of JNJ7777120 and JNJ10191584 was also beneficial for improving periodontal parameters. Conclusions: H4 receptor antagonists are able to ameliorate periodontitis-induced injury on SMG, gingival tissue and bone structure, suggesting that pharmacological targeting of H4R could be an attractive strategy to improve periodontal health.
format Artículo
author Prestifilippo, J. P.
Fernandez Solari, J.
Martinel Lamas, D.J.
Rios, C.E.
Mohn, C.
Perazzo, J.C.
Rivera, E.S.
Elverdin, J.C.
Medina, Vanina Araceli
author_facet Prestifilippo, J. P.
Fernandez Solari, J.
Martinel Lamas, D.J.
Rios, C.E.
Mohn, C.
Perazzo, J.C.
Rivera, E.S.
Elverdin, J.C.
Medina, Vanina Araceli
author_sort Prestifilippo, J. P.
title Pharmacological targeting of histamine H4 receptor in periodontal disease
title_short Pharmacological targeting of histamine H4 receptor in periodontal disease
title_full Pharmacological targeting of histamine H4 receptor in periodontal disease
title_fullStr Pharmacological targeting of histamine H4 receptor in periodontal disease
title_full_unstemmed Pharmacological targeting of histamine H4 receptor in periodontal disease
title_sort pharmacological targeting of histamine h4 receptor in periodontal disease
publisher John Wiley & Sons
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14561
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AT martinellamasdj pharmacologicaltargetingofhistamineh4receptorinperiodontaldisease
AT riosce pharmacologicaltargetingofhistamineh4receptorinperiodontaldisease
AT mohnc pharmacologicaltargetingofhistamineh4receptorinperiodontaldisease
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AT riveraes pharmacologicaltargetingofhistamineh4receptorinperiodontaldisease
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