Dendritic spine membrane proteome and its alterations in autistic spectrum disorder

Abstract: Dendritic spines are small protrusions stemming from the dendritic shaft that constitute the primary specialization for receiving and processing excitatory neurotransmission in brain synapses. The disruption of dendritic spine function in several neurological and neuropsychiatric diseases...

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Detalles Bibliográficos
Autores principales: Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Academic Press 2022
Materias:
AUTISMO
RECEPTOR DE ACETILCOLINA
SINAPTOPATIA
ESPINA DENDRITICA
SINDROME X FRAGIL
TRASTORNOS DEL ESPECTRO AUTISTA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14438
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14438
record_format dspace
spelling I33-R139-123456789-144382023-11-23T16:47:03Z Dendritic spine membrane proteome and its alterations in autistic spectrum disorder Vallés, Ana Sofía Barrantes, Francisco José AUTISMO RECEPTOR DE ACETILCOLINA SINAPTOPATIA ESPINA DENDRITICA SINDROME X FRAGIL TRASTORNOS DEL ESPECTRO AUTISTA Abstract: Dendritic spines are small protrusions stemming from the dendritic shaft that constitute the primary specialization for receiving and processing excitatory neurotransmission in brain synapses. The disruption of dendritic spine function in several neurological and neuropsychiatric diseases leads to severe information-processing deficits with impairments in neuronal connectivity and plasticity. Spine dysregulation is usually accompanied by morphological alterations to spine shape, size and/or number that may occur at early pathophysiological stages and not necessarily be reflected in clinical manifestations. Autism spectrum disorder (ASD) is one such group of diseases involving changes in neuronal connectivity and abnormal morphology of dendritic spines on postsynaptic neurons. These alterations at the subcellular level correlate with molecular changes in the spine proteome, with alterations in the copy number, topography, or in severe cases in the phenotype of the molecular components, predominantly of those proteins involved in spine recognition and adhesion, reflected in abnormally short lifetimes of the synapse and compensatory increases in synaptic connections. Since cholinergic neurotransmission participates in the regulation of cognitive function (attention, memory, learning processes, cognitive flexibility, social interactions) brain acetylcholine receptors are likely to play an important role in the dysfunctional synapses in ASD, either directly or indirectly via the modulatory functions exerted on other neurotransmitter receptor proteins and spine-resident proteins. 2022-07-14T17:35:53Z 2022-07-14T17:35:53Z 2022 Parte de libro Vallés, A.S., Barrantes, F.J. Dendritic spine membrane proteome and its alterations in autistic spectrum disorder [en línea]. En: Donev, R. (ed.). Advances in Protein Chemistry and Structural Biology: Volume 128 Membrane Proteins. Londres: Academic Press, 2022 doi:10.1016/bs.apcsb.2021.09.003 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14438 978-0-323-98895-7 1876-1623 https://repositorio.uca.edu.ar/handle/123456789/14438 10.1016/bs.apcsb.2021.09.003 35034726 eng info:eu-repo/semantics/closedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Academic Press Advances in Protein Chemistry and Structural Biology: Volume 128 Membrane Proteins. Londres: Academic Press, 2022
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic AUTISMO
RECEPTOR DE ACETILCOLINA
SINAPTOPATIA
ESPINA DENDRITICA
SINDROME X FRAGIL
TRASTORNOS DEL ESPECTRO AUTISTA
spellingShingle AUTISMO
RECEPTOR DE ACETILCOLINA
SINAPTOPATIA
ESPINA DENDRITICA
SINDROME X FRAGIL
TRASTORNOS DEL ESPECTRO AUTISTA
Vallés, Ana Sofía
Barrantes, Francisco José
Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
topic_facet AUTISMO
RECEPTOR DE ACETILCOLINA
SINAPTOPATIA
ESPINA DENDRITICA
SINDROME X FRAGIL
TRASTORNOS DEL ESPECTRO AUTISTA
description Abstract: Dendritic spines are small protrusions stemming from the dendritic shaft that constitute the primary specialization for receiving and processing excitatory neurotransmission in brain synapses. The disruption of dendritic spine function in several neurological and neuropsychiatric diseases leads to severe information-processing deficits with impairments in neuronal connectivity and plasticity. Spine dysregulation is usually accompanied by morphological alterations to spine shape, size and/or number that may occur at early pathophysiological stages and not necessarily be reflected in clinical manifestations. Autism spectrum disorder (ASD) is one such group of diseases involving changes in neuronal connectivity and abnormal morphology of dendritic spines on postsynaptic neurons. These alterations at the subcellular level correlate with molecular changes in the spine proteome, with alterations in the copy number, topography, or in severe cases in the phenotype of the molecular components, predominantly of those proteins involved in spine recognition and adhesion, reflected in abnormally short lifetimes of the synapse and compensatory increases in synaptic connections. Since cholinergic neurotransmission participates in the regulation of cognitive function (attention, memory, learning processes, cognitive flexibility, social interactions) brain acetylcholine receptors are likely to play an important role in the dysfunctional synapses in ASD, either directly or indirectly via the modulatory functions exerted on other neurotransmitter receptor proteins and spine-resident proteins.
format Parte de libro
author Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Vallés, Ana Sofía
title Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
title_short Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
title_full Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
title_fullStr Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
title_full_unstemmed Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
title_sort dendritic spine membrane proteome and its alterations in autistic spectrum disorder
publisher Academic Press
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14438
work_keys_str_mv AT vallesanasofia dendriticspinemembraneproteomeanditsalterationsinautisticspectrumdisorder
AT barrantesfranciscojose dendriticspinemembraneproteomeanditsalterationsinautisticspectrumdisorder
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