Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

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Abstract: The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin avb3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin av...

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Autores principales: Cayrol, María Florencia, Díaz Flaqué, María Celeste, Tharu, Fernando, Yang, Shao Ning, Sterle, Helena Andrea, Bolontrade, Marcela Fabiana, Amorós, Mariana, Isse, Blanca, Farías, Ricardo Norberto, Haelee, Ahn, Tian, Ye F., Tabbò, Fabrizio, Singh, Ankur, Inghirami, Giorgio, Cerchietti, Leandro, Cremaschi, Graciela A.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: American Society of Hematology 2019
Materias:
BIOLOGIA
MEDICINA
TUMORES
GLANDULA TIROIDES
HORMONAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1441
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-1441
record_format dspace
spelling I33-R139-123456789-14412024-03-07T13:06:33Z Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells Cayrol, María Florencia Díaz Flaqué, María Celeste Tharu, Fernando Yang, Shao Ning Sterle, Helena Andrea Bolontrade, Marcela Fabiana Amorós, Mariana Isse, Blanca Farías, Ricardo Norberto Haelee, Ahn Tian, Ye F. Tabbò, Fabrizio Singh, Ankur Inghirami, Giorgio Cerchietti, Leandro Cremaschi, Graciela A. BIOLOGIA MEDICINA TUMORES GLANDULA TIROIDES HORMONAS Abstract: The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin avb3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin avb3 ligands, activated growth-related signaling pathways in T-cell lymphomas (TCLs). Specifically, TH-activated avb3 integrin signaling promoted TCL proliferation and angiogenesis, in part, via the upregulation of vascular endothelial growth factor (VEGF). Consequently, genetic or pharmacologic inhibition of integrin avb3 decreased VEGF production and induced TCL cell death in vitro and in human xenograft models. In sum, weshowthat integrin avb3 transduces prosurvival signals into TCL nuclei, suggesting a novel mechanism for the endocrine modulation of TCL pathophysiology. Targeting this mechanism could constitute an effective and potentially low-toxicity chemotherapy-free treatment of TCL patients. 2019-05-02T13:56:12Z 2019-05-02T13:56:12Z 2015 Artículo Cayrol, F., et al. Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells [en línea]. Blood. 2015, 125 (5). doi:10.1182/blood-2014-07-587337. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1441 0006-4971 https://repositorio.uca.edu.ar/handle/123456789/1441 10.1182/blood-2014-07-587337 eng eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Society of Hematology Blood, 2015;125(5):841-851
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic BIOLOGIA
MEDICINA
TUMORES
GLANDULA TIROIDES
HORMONAS
spellingShingle BIOLOGIA
MEDICINA
TUMORES
GLANDULA TIROIDES
HORMONAS
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Tharu, Fernando
Yang, Shao Ning
Sterle, Helena Andrea
Bolontrade, Marcela Fabiana
Amorós, Mariana
Isse, Blanca
Farías, Ricardo Norberto
Haelee, Ahn
Tian, Ye F.
Tabbò, Fabrizio
Singh, Ankur
Inghirami, Giorgio
Cerchietti, Leandro
Cremaschi, Graciela A.
Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
topic_facet BIOLOGIA
MEDICINA
TUMORES
GLANDULA TIROIDES
HORMONAS
description Abstract: The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin avb3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin avb3 ligands, activated growth-related signaling pathways in T-cell lymphomas (TCLs). Specifically, TH-activated avb3 integrin signaling promoted TCL proliferation and angiogenesis, in part, via the upregulation of vascular endothelial growth factor (VEGF). Consequently, genetic or pharmacologic inhibition of integrin avb3 decreased VEGF production and induced TCL cell death in vitro and in human xenograft models. In sum, weshowthat integrin avb3 transduces prosurvival signals into TCL nuclei, suggesting a novel mechanism for the endocrine modulation of TCL pathophysiology. Targeting this mechanism could constitute an effective and potentially low-toxicity chemotherapy-free treatment of TCL patients.
format Artículo
author Cayrol, María Florencia
Díaz Flaqué, María Celeste
Tharu, Fernando
Yang, Shao Ning
Sterle, Helena Andrea
Bolontrade, Marcela Fabiana
Amorós, Mariana
Isse, Blanca
Farías, Ricardo Norberto
Haelee, Ahn
Tian, Ye F.
Tabbò, Fabrizio
Singh, Ankur
Inghirami, Giorgio
Cerchietti, Leandro
Cremaschi, Graciela A.
author_facet Cayrol, María Florencia
Díaz Flaqué, María Celeste
Tharu, Fernando
Yang, Shao Ning
Sterle, Helena Andrea
Bolontrade, Marcela Fabiana
Amorós, Mariana
Isse, Blanca
Farías, Ricardo Norberto
Haelee, Ahn
Tian, Ye F.
Tabbò, Fabrizio
Singh, Ankur
Inghirami, Giorgio
Cerchietti, Leandro
Cremaschi, Graciela A.
author_sort Cayrol, María Florencia
title Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
title_short Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
title_full Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
title_fullStr Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
title_full_unstemmed Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
title_sort integrin avb3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant t cells
publisher American Society of Hematology
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1441
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