Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism

Resumen: In-utero exposure to maternal stress increases short and long term risk of suffering metabolic diseases. Exposure to stressful events leads to an increase in glucocorticoids release by activation of the HPA axis, therefore early programming of the HPA axis has emerged as a key underlying me...

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Autores principales: Quiroga, Sofia, Juárez, Yamila R., Tellechea, Mariana L., Genaro, Ana María, Burgueño, Adriana
Formato: Documento de conferencia
Lenguaje:Inglés
Publicado: Fundación Revista Medicina 2022
Materias:
ESTRES PRENATAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14320
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14320
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTRES PRENATAL
spellingShingle ESTRES PRENATAL
Quiroga, Sofia
Juárez, Yamila R.
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
topic_facet ESTRES PRENATAL
description Resumen: In-utero exposure to maternal stress increases short and long term risk of suffering metabolic diseases. Exposure to stressful events leads to an increase in glucocorticoids release by activation of the HPA axis, therefore early programming of the HPA axis has emerged as a key underlying mechanism of stress-related disorders. Evidence suggests that a stressful prenatal environment seems to favour adverse metabolic conditions. To test this hypothesis in BALB/c mice, a strain susceptible to stress but resistant to metabolic effects of a high fat diet (HFD), we exposed female pregnant mice to restraint stress during the last week of pregnancy (2 h/day). Offspring were fed with HFD between weeks 4 and 28 of age. Prenatally stressed (PS) females and males fed with HFD showed higher body weight (females: p<0.001, n= 8; males: p<0.01, n= 8) and adipose tissue content (adipose tissue weight/body weight, both sexes: p<0.001, n= 8). Females were hyperinsulinemic (p<0.001, n= 5), with decreased expression of Foxo1 (Forkhead box protein O1) a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling (p<0.05, n= 5) and Adiponectin (p<0.05, n= 5) in adipose tissue. On the other hand, PS males (fed with standard or HFD) had hypertriglyceridemia (p<0.001, n= 8) and hypercholesterolemia (p<0.001, n= 8). PS per se, in males, decreased the expression of Adiponectin (p<0.01, n= 5). PS animals showed a great susceptibility to develop obesity. We conclude that PS may give rise to some adverse effects, and abnormal phenotype may be provoked by or exacerbated in a later life nutritional challenge. We intend to continue our research by evaluating whether epigenetic alterations are responsible for the observed gene expression alterations.
format Documento de conferencia
author Quiroga, Sofia
Juárez, Yamila R.
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
author_facet Quiroga, Sofia
Juárez, Yamila R.
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
author_sort Quiroga, Sofia
title Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
title_short Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
title_full Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
title_fullStr Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
title_full_unstemmed Effects of prenatal stress and postnatal high fat diet feeding on BALB/c mice metabolism
title_sort effects of prenatal stress and postnatal high fat diet feeding on balb/c mice metabolism
publisher Fundación Revista Medicina
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14320
work_keys_str_mv AT quirogasofia effectsofprenatalstressandpostnatalhighfatdietfeedingonbalbcmicemetabolism
AT juarezyamilar effectsofprenatalstressandpostnatalhighfatdietfeedingonbalbcmicemetabolism
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AT genaroanamaria effectsofprenatalstressandpostnatalhighfatdietfeedingonbalbcmicemetabolism
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bdutipo_str Repositorios
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