IL-1β, IL-2 and IL-4 concentration during porcine gestation

Abstract: In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the...

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Autores principales: Vélez, Carolina, Clauzure, Mariángeles, Williamson, Delia, Koncurat, Mirta A., Santa Coloma, Tomás Antonio, Barbeito, Claudio
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14303
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14303
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
spellingShingle ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
Vélez, Carolina
Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
IL-1β, IL-2 and IL-4 concentration during porcine gestation
topic_facet ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
description Abstract: In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the embryo and promotes the establishment of pregnancy. The aim of this work was to determine the concentration of IL-1β, IL-2 and IL-4 in sera and in extracts of maternal and fetal placenta from sows of different gestational periods. Reproductive tracts from 23 crossbreed sows, between 30 and 114 days of gestation (dg), and from 8 non-pregnant sows were used. The concentration of the cytokines was determined by ELISA. IL-1β, IL-2 and IL-4 demonstrated a similar pattern of concentration at the placental interface and serum; they were found elevated in tissues at 30 and 60-70 dg, and significantly decreased at term, period in which the cytokines were significantly increased in serum. These results show that IL-1β, IL-2, and IL-4 are differentially modulated during pregnancy and at term, and suggest an important role of these cytokines in defining the proinflammatory stage of these periods.
format Artículo
author Vélez, Carolina
Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
author_facet Vélez, Carolina
Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
author_sort Vélez, Carolina
title IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_short IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_full IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_fullStr IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_full_unstemmed IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_sort il-1β, il-2 and il-4 concentration during porcine gestation
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14303
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AT clauzuremariangeles il1bil2andil4concentrationduringporcinegestation
AT williamsondelia il1bil2andil4concentrationduringporcinegestation
AT koncuratmirtaa il1bil2andil4concentrationduringporcinegestation
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