Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway

Abstract: Sepsis, a systemic inflammatory response syndrome (SIRS) caused by infection, is a major public health concern with limited therapeutic options. Infection disturbs the homeostasis of host, resulting in excessive inflammation and immune suppression. This has prompted the clinical use of imm...

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Autores principales: Zhang, Ye, Yang, Xue, Yan, Wenchao, Li, Rui, Ye, Qian, You, Linjun, Xie, Wenhao, Mo, Kun, Fu, Ruifeng, Wang, Yanxiang, Chen, Yufei, Hou, Hui, Yang, Yong, Birnbaumer, Lutz, Di, Qin, Li, Xianjing
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2022
Materias:
CITOQUINAS
INFLAMACION
SEPSIS
TIMOPENTINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14248
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14248
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CITOQUINAS
INFLAMACION
SEPSIS
TIMOPENTINA
spellingShingle CITOQUINAS
INFLAMACION
SEPSIS
TIMOPENTINA
Zhang, Ye
Yang, Xue
Yan, Wenchao
Li, Rui
Ye, Qian
You, Linjun
Xie, Wenhao
Mo, Kun
Fu, Ruifeng
Wang, Yanxiang
Chen, Yufei
Hou, Hui
Yang, Yong
Birnbaumer, Lutz
Di, Qin
Li, Xianjing
Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
topic_facet CITOQUINAS
INFLAMACION
SEPSIS
TIMOPENTINA
description Abstract: Sepsis, a systemic inflammatory response syndrome (SIRS) caused by infection, is a major public health concern with limited therapeutic options. Infection disturbs the homeostasis of host, resulting in excessive inflammation and immune suppression. This has prompted the clinical use of immunomodulators to balance host response as an alternative therapeutic strategy. Here, we report that Thymopentin (TP5), a synthetic immunomodulator pentapeptide (Arg-Lys-Asp-Val-Tyr) with an excellent safety profile in the clinic, protects mice against cecal ligation and puncture (CLP)-induced sepsis, as shown by improved survival rate, decreased level of pro-inflammatory cytokines and reduced ratios of macrophages and neutrophils in spleen and peritoneum. Regarding mechanism, TP5 changed the characteristics of LPS-stimulated macrophages by increasing the production of 15-deoxy-Δ12,14 -prostaglandin J2 (15-d-PGJ2). In addition, the improved effect of TP5 on survival rates was abolished by the peroxisome proliferator-activated receptor γ (PPARγ) antagonist GW9662. Our results uncover the mechanism of the TP5 protective effects on CLP-induced sepsis and shed light on the development of TP5 as a therapeutic strategy for lethal systemic inflammatory disorders.
format Artículo
author Zhang, Ye
Yang, Xue
Yan, Wenchao
Li, Rui
Ye, Qian
You, Linjun
Xie, Wenhao
Mo, Kun
Fu, Ruifeng
Wang, Yanxiang
Chen, Yufei
Hou, Hui
Yang, Yong
Birnbaumer, Lutz
Di, Qin
Li, Xianjing
author_facet Zhang, Ye
Yang, Xue
Yan, Wenchao
Li, Rui
Ye, Qian
You, Linjun
Xie, Wenhao
Mo, Kun
Fu, Ruifeng
Wang, Yanxiang
Chen, Yufei
Hou, Hui
Yang, Yong
Birnbaumer, Lutz
Di, Qin
Li, Xianjing
author_sort Zhang, Ye
title Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
title_short Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
title_full Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
title_fullStr Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
title_full_unstemmed Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway
title_sort thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin j2 and activating the pparγ signaling pathway
publisher Wiley
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14248
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