The contribution of biophysics and structural biology to current advances in COVID-19

Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over...

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Detalles Bibliográficos
Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Annual Reviews 2022
Materias:
COVID-19
PROTEINAS
ESTRUCTURA MOLECULAR
BIOFISICA
BIOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14239
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14239
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic COVID-19
PROTEINAS
ESTRUCTURA MOLECULAR
BIOFISICA
BIOLOGIA
spellingShingle COVID-19
PROTEINAS
ESTRUCTURA MOLECULAR
BIOFISICA
BIOLOGIA
Barrantes, Francisco José
The contribution of biophysics and structural biology to current advances in COVID-19
topic_facet COVID-19
PROTEINAS
ESTRUCTURA MOLECULAR
BIOFISICA
BIOLOGIA
description Abstract: Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membraneboundmetalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title The contribution of biophysics and structural biology to current advances in COVID-19
title_short The contribution of biophysics and structural biology to current advances in COVID-19
title_full The contribution of biophysics and structural biology to current advances in COVID-19
title_fullStr The contribution of biophysics and structural biology to current advances in COVID-19
title_full_unstemmed The contribution of biophysics and structural biology to current advances in COVID-19
title_sort contribution of biophysics and structural biology to current advances in covid-19
publisher Annual Reviews
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14239
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