Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity

Abstract: Purpose Hypothyroidism has been shown to induce immunosuppression and both the thyroid status and immunity are affected by zinc deficiency. However, the impact of hypothyroidism on zinc metabolism and its possible relationship with the immune status has not yet been deeply explored. Here...

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Autores principales: Paulazo, Maria Alejandra, Klecha, Alicia Juana, Sterle, Helena Andrea, Valli, Eduardo, Torti, Horacio, Cayrol, María Florencia, Barreiro Arcos, María Laura, Cremaschi, Graciela A.
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2022
Materias:
GLANDULA TIROIDES
HIPOTIROIDISMO
LINFOCITOS T
ZINC
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14235
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14235
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic GLANDULA TIROIDES
HIPOTIROIDISMO
LINFOCITOS T
ZINC
spellingShingle GLANDULA TIROIDES
HIPOTIROIDISMO
LINFOCITOS T
ZINC
Paulazo, Maria Alejandra
Klecha, Alicia Juana
Sterle, Helena Andrea
Valli, Eduardo
Torti, Horacio
Cayrol, María Florencia
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
topic_facet GLANDULA TIROIDES
HIPOTIROIDISMO
LINFOCITOS T
ZINC
description Abstract: Purpose Hypothyroidism has been shown to induce immunosuppression and both the thyroid status and immunity are affected by zinc deficiency. However, the impact of hypothyroidism on zinc metabolism and its possible relationship with the immune status has not yet been deeply explored. Here, our aim was to study whether hypothyroidism may alter zinc metabolism and thus lead to the impairment of T lymphocyte activity. Methods Variations in the distribution of zinc in the body were evaluated in PTU-treated hypothyroid mice. The effects of hypothyroidism and zinc deficiency were studied on T lymphocyte proliferation after stimulation both in vitro and in vivo. For in vitro assays, thyroid hormone-free or zinc chelator (TPEN or DTPA)-supplemented media were used. For in vivo assays, lymphocyte activity was evaluated in cells from hypothyroid, T3-treated, and zinc-supplemented mice. Results Hypothyroid mice showed lower levels of zinc in femur and lymph nodes than controls. T3 and zinc supplementation reversed these effects. In vitro, both thyroid hormone and zinc deficiency led to a decreased response to mitogen stimulation. However, only zinc deficiency was able to induce lymphocyte apoptosis. Mitogen-stimulated T cells from hypothyroid mice showed impaired proliferation, accompanied by decreased activation of PKC and lower levels of p-ERK, effects that were reversed by T3 replacement or zinc supplementation. Conclusions Our results show an important role of zinc deficiency in hypothyroid-mediated T-cell suppression and suggest the importance of evaluating zinc levels and restoring them when necessary to maintain an efficient immune response in hypothyroid patients.
format Artículo
author Paulazo, Maria Alejandra
Klecha, Alicia Juana
Sterle, Helena Andrea
Valli, Eduardo
Torti, Horacio
Cayrol, María Florencia
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
author_facet Paulazo, Maria Alejandra
Klecha, Alicia Juana
Sterle, Helena Andrea
Valli, Eduardo
Torti, Horacio
Cayrol, María Florencia
Barreiro Arcos, María Laura
Cremaschi, Graciela A.
author_sort Paulazo, Maria Alejandra
title Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
title_short Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
title_full Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
title_fullStr Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
title_full_unstemmed Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity
title_sort hypothyroidism-related zinc deficiency leads to suppression of t lymphocyte activity
publisher Springer
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14235
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