Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports

Abstract: The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings of peace, bliss and timelessness, life review, the sensation of traveling through a tun...

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Autores principales: Martial, Charlotte, Cassol, Helena, Charland-Verville, Vanessa, Pallavicini, Carla, Sanz, Camila, Zamberlan, Federico, Martínez Vivot, Rocío, Erowid, Fire, Erowid, Earth, Laureys, Steven, Greyson, Bruce, Tagliazucchi, Enzo
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
MUERTE
FENOMENOLOGIA
SUSTANCIAS PSICOACTIVAS
FARMACOLOGIA
ALUCINOGENOS
CONCIENCIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14227
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14227
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MUERTE
FENOMENOLOGIA
SUSTANCIAS PSICOACTIVAS
FARMACOLOGIA
ALUCINOGENOS
CONCIENCIA
spellingShingle MUERTE
FENOMENOLOGIA
SUSTANCIAS PSICOACTIVAS
FARMACOLOGIA
ALUCINOGENOS
CONCIENCIA
Martial, Charlotte
Cassol, Helena
Charland-Verville, Vanessa
Pallavicini, Carla
Sanz, Camila
Zamberlan, Federico
Martínez Vivot, Rocío
Erowid, Fire
Erowid, Earth
Laureys, Steven
Greyson, Bruce
Tagliazucchi, Enzo
Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
topic_facet MUERTE
FENOMENOLOGIA
SUSTANCIAS PSICOACTIVAS
FARMACOLOGIA
ALUCINOGENOS
CONCIENCIA
description Abstract: The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings of peace, bliss and timelessness, life review, the sensation of traveling through a tunnel and an irreversible threshold. Near-death experiences (NDEs) are comparable among individuals of different cultures, suggesting an underlying neurobiological mechanism. Anecdotal accounts of the similarity between NDEs and certain drug-induced altered states of consciousness prompted us to perform a large-scale comparative analysis of these experiences. After assessing the semantic similarity between ≈15,000 reports linked to the use of 165 psychoactive substances and 625 NDE narratives, we determined that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine consistently resulted in reports most similar to those associated with NDEs. Ketamine was followed by Salvia divinorum (a plant containing a potent and selective κ receptor agonist) and a series of serotonergic psychedelics, including the endogenous serotonin 2A receptor agonist N,N-Dimethyltryptamine (DMT). This similarity was driven by semantic concepts related to consciousness of the self and the environment, but also by those associated with the therapeutic, ceremonial and religious aspects of drug use. Our analysis sheds light on the long-standing link between certain drugs and the experience of "dying", suggests that ketamine could be used as a safe and reversible experimental model for NDE phenomenology, and supports the speculation that endogenous NMDA antagonists with neuroprotective properties may be released in the proximity of death.
format Artículo
author Martial, Charlotte
Cassol, Helena
Charland-Verville, Vanessa
Pallavicini, Carla
Sanz, Camila
Zamberlan, Federico
Martínez Vivot, Rocío
Erowid, Fire
Erowid, Earth
Laureys, Steven
Greyson, Bruce
Tagliazucchi, Enzo
author_facet Martial, Charlotte
Cassol, Helena
Charland-Verville, Vanessa
Pallavicini, Carla
Sanz, Camila
Zamberlan, Federico
Martínez Vivot, Rocío
Erowid, Fire
Erowid, Earth
Laureys, Steven
Greyson, Bruce
Tagliazucchi, Enzo
author_sort Martial, Charlotte
title Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
title_short Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
title_full Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
title_fullStr Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
title_full_unstemmed Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
title_sort neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14227
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