Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice

Abstract: The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer ce...

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Autores principales: Roldán Deamicis, Agustina, Alonso, Eliana, Brie, Belén, Braico, Diego Aguilera, Balogh, Gabriela Andrea
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2022
Materias:
CANCER DE MAMA
CARCINOGENESIS
PREVENCION DE ENFERMEDADES
Maitake Pro4X
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14225
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14225
record_format dspace
spelling I33-R139-123456789-142252023-11-22T22:12:43Z Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice Roldán Deamicis, Agustina Alonso, Eliana Brie, Belén Braico, Diego Aguilera Balogh, Gabriela Andrea CANCER DE MAMA CARCINOGENESIS PREVENCION DE ENFERMEDADES Maitake Pro4X Abstract: The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties. D-Fraction, an extract of Maitake (from the edible Grifola frondosa mushroom), rich in β-glucans, exert notable effects in the immune system. Until now, some published articles suggest that Maitake D-Fraction could have anti-tumoral activity, prevent oncogenesis and metastasis in some tumor types. However, there are no clear data about Maitake D-Fraction action on breast cancer prevention and its exact molecular mechanisms are not yet elucidated. The experiments were performed employing 25 female BALBc mice that were treated with and without Maitake D-Fraction Pro4X or Maitake Standard for 15 days by daily intraperitoneal injection. After treatment period, all mice were implanted with murine tumor cells LM3 to induce mammary tumorigenesis. Animals were checked weekly and killed after 46 days of LM3 transplant; percentage of cancer prevention, rate of tumor growing, and overall survival were determined. Under dissection, the internal organs were evaluated histologically and genetically by RT-PCR. We found that 5 mg/kg per day of Maitake D-Fraction Pro4X, administered dairy during 15 days to BALBc mice was able to block more than 60% breast cancer development. However, Maitake Standard prevents oncogenesis in 26% to respect control. In this work, we found that Maitake D-Fraction Pro4X, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival. 2022-06-22T12:43:47Z 2022-06-22T12:43:47Z 2016 Artículo Roldán Deamicis, A. et al. Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice [en línea]. Cancer Medicine. 2016, 5(9):2427–2441 doi:10.1002/cam4.744 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14225 2045-7634 https://repositorio.uca.edu.ar/handle/123456789/14225 10.1002/cam4.744 27401257 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Cancer Medicine. 2016, 5(9):2427–2441
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER DE MAMA
CARCINOGENESIS
PREVENCION DE ENFERMEDADES
Maitake Pro4X
spellingShingle CANCER DE MAMA
CARCINOGENESIS
PREVENCION DE ENFERMEDADES
Maitake Pro4X
Roldán Deamicis, Agustina
Alonso, Eliana
Brie, Belén
Braico, Diego Aguilera
Balogh, Gabriela Andrea
Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
topic_facet CANCER DE MAMA
CARCINOGENESIS
PREVENCION DE ENFERMEDADES
Maitake Pro4X
description Abstract: The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties. D-Fraction, an extract of Maitake (from the edible Grifola frondosa mushroom), rich in β-glucans, exert notable effects in the immune system. Until now, some published articles suggest that Maitake D-Fraction could have anti-tumoral activity, prevent oncogenesis and metastasis in some tumor types. However, there are no clear data about Maitake D-Fraction action on breast cancer prevention and its exact molecular mechanisms are not yet elucidated. The experiments were performed employing 25 female BALBc mice that were treated with and without Maitake D-Fraction Pro4X or Maitake Standard for 15 days by daily intraperitoneal injection. After treatment period, all mice were implanted with murine tumor cells LM3 to induce mammary tumorigenesis. Animals were checked weekly and killed after 46 days of LM3 transplant; percentage of cancer prevention, rate of tumor growing, and overall survival were determined. Under dissection, the internal organs were evaluated histologically and genetically by RT-PCR. We found that 5 mg/kg per day of Maitake D-Fraction Pro4X, administered dairy during 15 days to BALBc mice was able to block more than 60% breast cancer development. However, Maitake Standard prevents oncogenesis in 26% to respect control. In this work, we found that Maitake D-Fraction Pro4X, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival.
format Artículo
author Roldán Deamicis, Agustina
Alonso, Eliana
Brie, Belén
Braico, Diego Aguilera
Balogh, Gabriela Andrea
author_facet Roldán Deamicis, Agustina
Alonso, Eliana
Brie, Belén
Braico, Diego Aguilera
Balogh, Gabriela Andrea
author_sort Roldán Deamicis, Agustina
title Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
title_short Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
title_full Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
title_fullStr Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
title_full_unstemmed Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice
title_sort maitake pro4x has anti-cancer activity and prevents oncogenesis in balbc mice
publisher Wiley
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14225
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AT braicodiegoaguilera maitakepro4xhasanticanceractivityandpreventsoncogenesisinbalbcmice
AT baloghgabrielaandrea maitakepro4xhasanticanceractivityandpreventsoncogenesisinbalbcmice
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