Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth

Abstract: Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell...

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Autores principales: Barreiro Arcos, María Laura, Sterle, Helena Andrea, Cayrol, María Florencia, Díaz Flaqué, María Celeste, Valli, Eduardo, Paulazo, Maria Alejandra, Klecha, Alicia Juana, Cremaschi, Graciela A.
Formato: Artículo
Lenguaje:Inglés
Publicado: Bentham Science Publishers 2022
Materias:
GLANDULA TIROIDES
HORMONAS
TUMORES
LINFOMA DE CELULAS T
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14054
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14054
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic GLANDULA TIROIDES
HORMONAS
TUMORES
LINFOMA DE CELULAS T
spellingShingle GLANDULA TIROIDES
HORMONAS
TUMORES
LINFOMA DE CELULAS T
Barreiro Arcos, María Laura
Sterle, Helena Andrea
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Valli, Eduardo
Paulazo, Maria Alejandra
Klecha, Alicia Juana
Cremaschi, Graciela A.
Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
topic_facet GLANDULA TIROIDES
HORMONAS
TUMORES
LINFOMA DE CELULAS T
description Abstract: Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signal-regulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin V3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas.
format Artículo
author Barreiro Arcos, María Laura
Sterle, Helena Andrea
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Valli, Eduardo
Paulazo, Maria Alejandra
Klecha, Alicia Juana
Cremaschi, Graciela A.
author_facet Barreiro Arcos, María Laura
Sterle, Helena Andrea
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Valli, Eduardo
Paulazo, Maria Alejandra
Klecha, Alicia Juana
Cremaschi, Graciela A.
author_sort Barreiro Arcos, María Laura
title Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
title_short Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
title_full Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
title_fullStr Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
title_full_unstemmed Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
title_sort classical and non-classical thyroid hormone intracellular pathways involved in t lymphoma growth
publisher Bentham Science Publishers
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14054
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