Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment

Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers a...

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Autores principales: Aguilera Braico, Diego, Roldán Deamicis, Agustina, Brie, Belén, Balogh, Gabriela Andrea
Formato: Artículo
Lenguaje:Inglés
Publicado: Omics International 2022
Materias:
CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14053
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14053
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
spellingShingle CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
topic_facet CANCER DE MAMA
Maitake Pro4X
QUIMIOTERAPIA
description Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.
format Artículo
author Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
author_facet Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
author_sort Aguilera Braico, Diego
title Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_short Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_full Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_fullStr Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_full_unstemmed Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
title_sort comparative effect of maitake pro4x with chemotherapy breast cancer treatment
publisher Omics International
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14053
work_keys_str_mv AT aguilerabraicodiego comparativeeffectofmaitakepro4xwithchemotherapybreastcancertreatment
AT roldandeamicisagustina comparativeeffectofmaitakepro4xwithchemotherapybreastcancertreatment
AT briebelen comparativeeffectofmaitakepro4xwithchemotherapybreastcancertreatment
AT baloghgabrielaandrea comparativeeffectofmaitakepro4xwithchemotherapybreastcancertreatment
bdutipo_str Repositorios
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